α-1受体阻滞剂在治疗碎石后石街形成的临床研究  

The Clinical Study of α-1 Receptor Blocker in Treatment of Calculi Street

作　　者：谢国祥 

机构地区：[1]贵州省铜仁市中医院外科,554300

出　　处：《中国医药指南》2010年第9期31-32,共2页Guide of China Medicine

摘　　要：目的探讨α-1受体阻滞剂坦索罗辛对碎石后石街形成的疗效。方法碎石后输尿管下段石街形成患者60例,分为两组,对照组30例,常规治疗:口服排石颗粒20.0g,2次/d,4周,同时每日饮水约2000mL;治疗组30例,常规治疗+口服坦索罗辛0.4mg,1次/d,4周,同时每日饮水约2000mL。结果对照组结石排出率51.12%,平均排出时间(12±8)d,治疗期间肾绞痛平均发作3.0次;治疗组结石排出率85.39%,平均排出时间(6±4)d,治疗期间肾绞痛平均发作1.0次;两组排出率比较差异有显著性(P<0.05)。结论α-1受体阻滞剂坦索罗辛治疗输尿管下段结石能明显提高结石排出率,缩短排出时间,减少治疗期问肾绞痛的发作次数。Objective To assess the effect of alpha 1 receptors blocker （tamsulosm） m treatment ot calculi street locattzea in the lower ureters, Methods from December 2005 to December 2008, 60 patients with calculi street in the lower ureters were randomly divided into two groups： group A（n=30）was subjected to our regular treatment（20.0g PSKL rid）and group B（n=30）was regular treatment combined with tamsulosin 0.4mg qd. Results In group A, 53.33% of the patients expelled the calculis and was lower than 86.67% in group B.The mean time discharged calculis in group A was more longer and incidence of renal colics more frequent, compared with group B[（ 12±8）days vs. （6±4）days, 3.0 times vs 1.0 times,respectively）]. Conclusion The treatment by alpha 1 receptors blocker （tamsulosin） can accelerate crushed calculi discharge from the lower ureters and be safety.

关 键 词：α-1受体阻滞剂 石街 

分 类 号：R693.4[医药卫生—泌尿科学]