553株亚胺培南病原菌分布与耐药分析  

Distribution and Analysis of 553 Imipenem-resistant Strains

作　　者：万梅玲[1] 杨青[2] 

机构地区：[1]徐州医学院附属医院,江苏徐州221002 [2]徐州市中心医院,江苏徐州2210092

出　　处：《抗感染药学》2010年第1期48-50,共3页Anti-infection Pharmacy

摘　　要：目的:了解对亚胺培南耐药菌株对抗菌药物的敏感性及临床用药情况,为临床合理用药提供参考。方法:通过HIS系统调取2009年1—6月对亚胺培南耐药的83例患者的资料,记录患者基本情况及抗菌药物应用情况,经细菌学培养及药敏结果,分析对亚胺培南耐药的原因。结果:临床分离的耐亚胺培南菌株553株,其中铜绿假单胞菌18.63%(103/553)、鲍曼不动杆菌2.17%(12/553)、大肠埃希菌20.98%(116/553)、肺炎克雷伯菌13.21%(73/553)、鲍曼复合醋酸钙不动杆菌7.59%(42/553)、白色假丝酵母菌8.50%(47/553)、光滑念珠菌4.88%(27/553)、其他24.05%(133/553)等菌株。耐亚胺培南菌株对β内酰胺类抗菌药物具有高度耐药。结论:耐亚胺培南菌株大多存在多重耐-药性,临床应根据药敏试验结果选用对耐亚胺培南菌株敏感的抗菌药物。Objective： To study the sensitivity to antibiotics of imipenem-resistant strains, and clinical medication situation,and to rationalize the clinical medication. Methods： Through the HIS system from Jan. 2009 to Jun. on the 83 imipenem-resistant patients, we recorded patients basic information and the use of antimicrobial agents, statistics bacterial raise and sensitivity results, and analyzed the reasons for resistance to imipenem. Results： Five hundred and fifly-three（553） strains of imipenem-resistant were separated and the rates of resistance were Pseudomonas aenlginosa 18.63%（103/553）, A.baumanii 2.17%（12/553）, Escherichia coli 20.98%（116/553）, Klebsiella pneumoniae 13.21%（73/553）, A.calcoaceticus 7.59%（42/553）, C.albicans 8.50%（47/553）, Candida glabrata 4.88%0（27/553）, and others 24.05%（133/553） respectively, lmipenem-resistant strains were highly resistant to β-lactam antibiotics. Conclusion： Most imipenem-resistant strains have multiple drug resistances and so people should select the antibiotics that sensitive to imipenem-resistant strains in the clinical medication.

关 键 词：亚胺培南 抗菌药物 耐药性 

分 类 号：R956[医药卫生—药学] R978