抗-GBM及抗-MPO检测对SLE的诊断价值  

The diagnostic values of anti-GBM and anti-MPO in patients with systemic lupus erythematosus

作　　者：李峥嵘 王伟鑫 李忠信 罗纯苑 

机构地区：[1]广东省东莞市康华医院检验科,广东东莞523080

出　　处：《实验与检验医学》2010年第1期19-20,共2页Experimental and Laboratory Medicine

摘　　要：目的探讨抗肾小球基底膜抗体(Anti-GBM)及抗中性粒细胞胞浆抗体髓过氧化物酶(Anti-MPO)在系统性红斑狼疮(SLE)中的诊断价值。方法采用线性免疫分析法,检测46例SLE及30例健康(对照组)血清抗-GBM抗体和抗-MPO抗体。结果SLE组血清抗-GBM阳性率为47.8%,抗-MPO阳性率为13.0%,与对照组差异有统计学意义(P<0.05)。结论SLE易出现肾脏损害及全身血管炎疾病,抗-GBM及抗-MPO可作为诊断SLE患者肾脏受损及血管炎疾病的参考指标,对SLE患者并发症的诊断治疗有一定的价值。Objestive To investigate the diagnostic values of anti-glomerular basement membrane antibody （anti-GBM） and anti-myeloperoxidase antibody （anti-MPO） in patients with systemic lupus erythematosus （SLE）. Method Serum anti-GBM and anti-MPO were determined in patients （n=46）and the controls （n=30） by linear immuno assay. Results The positive rates of anti-GBM and anti-MPO in the SLE group were 47.8% and 13.0%, showing higher than those of the control group （P〈0.05）. Conclusion Anti-GBM and anti-MPO levels can be used as the reference parameters in SLE patients with kidney damage and systemic vasulitides, and may be helpful for the diagnosis and therapy of SLE with complication.

关 键 词：系统性红斑狼疮 抗肾小球基底膜抗体 髓过氧化物酶抗体 

分 类 号：R446.62[医药卫生—诊断学] R593.241[医药卫生—临床医学]