自身免疫抗体检查对乳糜泻诊断的价值和意义  

The evaluation of autoimmune antibody detection on the diagnosis of celiac disease

作　　者：李明[1] 孙芾[1] 纪开宇[2] 崔玉涛[3] 李永哲[4] 

机构地区：[1]北京和睦家医院检验科 [2]北京和睦家医院内科 [3]北京和睦家医院儿科 [4]北京协和医院检验科,100016

出　　处：《实验与检验医学》2010年第1期29-30,36,共3页Experimental and Laboratory Medicine

摘　　要：目的评价自身免疫性抗体对乳糜泻诊断的价值和意义。方法对2005年起,来我院就诊的长期慢性腹胀腹泻、具有乳糜泻症状的147例病人进行7种自身免疫性抗体检测:抗麦胶蛋白IgA和IgG抗体、抗肌内膜IgA和IgG抗体、抗网硬蛋白IgG和IgA抗体、抗组织转谷氨酰胺酶IgA抗体。结果有一项抗体阳性38例,二或三项抗体阳性14例。抗麦胶蛋白IgA和IgG抗体、抗肌内膜IgA抗体阳性率分别为53.6%、64.3%、32.1%,网硬蛋白IgG及IgA抗体阳性率为0。在部分抗体检查结果阳性并进行小肠黏膜活检的10名患者中,检测到不同程度的黏膜绒毛萎缩变化。结论麦胶蛋白IgA和IgG抗体、肌内膜IgA抗体用于乳糜泻检测有较高的阳性率。Objectives To evaluate the value of autoimmune antibody detection on the diagnosis of celiac disease. Method 7 kinds of antibodies were detected from 147 patients with celiac disease symptoms, including antibodies of antigliadin IgA and IgG, endomysium IgA and IgG antibodies, Anti-reticulin IgG and IgA, anti-tissue transglutaminase IgA. Results Among 147 cases, 34 cases showed one kind of antibody; 14 cases showed two or three kinds of antibodies. The positive ratios of antigliadin IgA, IgG and endomysium IgA antibodies were 53.6% ,64.3% and 25% respectively. Furthermore, all of anti-reticulin antibodies showed negative. The histopathologic samples of intestinal mucosa from 10 patients with the positive autoimmune antibody existed villus atrophy. Conclusions Endomysium IgA antibody, antigliadin IgA and IgG antibodiesare of value for the diagnosis of celiac disease.

关 键 词：乳糜泻 自身免疫抗体 诊断 

分 类 号：R723.13[医药卫生—儿科] R446.62[医药卫生—临床医学]