Sodium tetrachloroaurate(III) dihydrate-catalyzed efficient synthesis of 1,5-benzodiazepine and quinoxaline derivatives  

作　　者：Ren-xin SHI Yun-kui LIU Zhen-yuan XU 

机构地区：[1]State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology, Hangzhou 310014, China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2010年第2期102-108,共7页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：Project supported by the Natural Science Foundation of Zhejiang Province (No. Y407168);the Foundation of Education of Zhejiang Province (No. Z200803599);the Opening Foundation of Zhejiang Provincial Top Key Discipline (No. 56310101634), China

摘　　要：Both 1,5-benzodiazepine and quinoxaline derivatives are important heterocycles in pharmaceuticals. We describe an efficient and clean method for the synthesis of 1,5-benzodiazepines from o-phenylenediamine and ketones catalyzed by sodium tetrachloroaurate（Ⅲ） dihydrate under mild conditions. The catalyst was shown to be equally effective for the synthesis of quinoxalines from o-phenylenediamine and α-bromo ketones under the similar reaction conditions. This method produced good yields.Both 1,5-benzodiazepine and quinoxaline derivatives are important heterocycles in pharmaceuticals. We describe an efficient and clean method for the synthesis of 1,5-benzodiazepines from o-phenylenediamine and ke-tones catalyzed by sodium tetrachloroaurate(III) dihydrate under mild conditions. The catalyst was shown to be equally effective for the synthesis of quinoxalines from o-phenylenediamine and α-bromo ketones under the similar reaction conditions. This method produced good yields.

关 键 词：1 5-benzodiaepines O-PHENYLENEDIAMINE KETONES QUINOXALINES Gold catalyst 

分 类 号：O625.322[理学—有机化学] TQ246.31[理学—化学]