^18F—FDG PET—CT和双源CT的Lung Care软件在评估孤立性肺结节中的比较研究  

Utility of ^18F-FDG PET/CT in the Evaluation of Solitary Pulmonary Nodule： A Comparative Study with LungCare Software of Dual Source CT

作　　者：王华斌[1] 李苏建[1] 王中秋[1] 卢光明[1] 

机构地区：[1]南京大学医学院临床学院南京军区南京总医院医学影像科,江苏南京210002

出　　处：《实用放射学杂志》2010年第2期175-178,共4页Journal of Practical Radiology

摘　　要：目的探讨^18-氟-脱氧葡萄糖（^18F—FDG）PET／CT显像及Siemens双源CT的LungCare软件对孤立性肺结节（SPN）的辅助诊断能力及适用范围。方法回顾分析经病理证实的24例SPN患者的PET—CT图像资料，并与利用双源CT的LungCare软件分析SPN进行比较研究。用x^2检验对2种检查方法的评价结果进行统计学分析，以P〈0．05作为差异有显著意义。结果在24例SPN中，恶性结节15例，良性结节9例。LungCare软件评估其良恶性的准确性、敏感性、特异性、阳性预测值、阴性预测值分别为83．3％、80．0％、88．8％、92．3％、72．7％；PET—CT评估其良恶性的准确性、敏感性、特异性、阳性预测值、阴性预测值分别为87．5％、93．3％、77．7％，87．5％、87．5％。LungCare软件和PET／CT定性SPN的准确性相当，两者之间并不存在明显的差异（P〉0．05）。PET／CT的敏感性、阴性预测值明显高于LungCare软件，但其特异性、阳性预测值明显低于LungCare软件（P〈0．05）。结论^18F—FDGPET—CT对肺结节的诊断有一定辅助作用，适用于对孤立性肺结节的良恶性鉴别诊断。PET／CT密切结合LungCare软件，可进一步提高诊断正确率。Objective To evaluate the auxiliary diagnostic ability and applicability of ^18 F-FDG PET/CT and the LungCare software of dual source CT in solitary pulmonary nodule{SPN）. Methods 28 patients with SPN proved by pathologically were examined by ^18 F-FDG PET/CT and LungCare software of dual source CT. ^18 F-FDG PET/CT and LungCare software of dual source CT data were analysed comparatively in terms of the diagnostic accuracy in distinguishing malignant and benign. All data were analyzed for significance by using the x^2 -test,the value of P〈0.05 was accepted as significance. Results There were 15 malignant and 9 benign nodules. In evaluating SPN, the diagnostic sensitivity,specificity,accuracy,positive predictive value and negative predictive value were 80.0%,88.8% ,83.3% ,92.3% and 72.7% with^18 F-FDG PET/CT respectively,and 93.3% ,77.7% ,87.5%,87.5% and 87.5% with LungCare software, respectively. To evaluate SPN, LungCare software and ^18 F-FDG PET/CT was not significant difference in accuracy（P〉0. 05）,while there were significant differences in sensitivity , specificity , positive and negative predictive value （ P〈 0.05 ）. The sensitivity and negative predictive values with^18 F- FDG PET/CT were much better than that with LungCare software, but the specificity and positive predictive values were less than that with LungCare software. Conclusion^ 18 F--FDG PET/CT has certain auxiliary function in distinguishing benign SPN from malignant SPN,it combining with LungCare software , the accuracy of diagnosis can be improved.

关 键 词：肺 孤立性肺结节 正电子发射断层显像术 计算机体层摄影 双源 

分 类 号：R563[医药卫生—呼吸系统] R814.42[医药卫生—内科学]