^1H MRS对椎体骨髓研究初步应用  

Study of ^1H MR Spectroscopy of Vertebral Body Marrow

作　　者：刘勇[1] 汤光宇[1] 汤榕彪[1] 姚冀平[1] 李伟[1] 赵文荣[1] 

机构地区：[1]同济大学附属上海市第十人民医院放射科,上海200072

出　　处：《实用放射学杂志》2010年第2期219-223,共5页Journal of Practical Radiology

基　　金：上海市科委基础研究重点项目（08JC1419500）.

摘　　要：目的探讨椎体骨髓脂肪含量（fat fraction，FF）在不同年龄组、性别的变化规律及与骨密度（bone mineral densities，BMD）的相关性。方法对85名年龄21～70岁健康志愿者及20名已行腰椎双能量X线吸收测定（dualx—ray absorptionmetry，DXA）诊断为骨质疏松的老年男女进行前瞻性MR波谱分析，测定L3椎体脂肪分数值（fatfraction，FF）。健康志愿者按每10岁为一个年龄段，将其分为5组，每组16～18人。结果21～30岁组、31～40岁组、41～50岁组、51～60岁组、〉60岁组和骨质疏松组的FF分别为30．7％±4．4％、35．5％±6．8％、41．9％±6．6％、46．8％±5．5％、51．7％±5．2％和59．2％±7．4％；除〉60岁组和骨质疏松组外，各组L3椎体脂肪含量男性均比女性高（P〈0．05），其中，41～50岁组中的男女差别最大，达11．1％。骨质疏松组FF与BMD呈负相关关系（y=-0．6，P〈0．01）。结论正常椎体骨髓脂肪含量随年龄而逐渐增加，^1H MRS可作为评价骨质量的新手段。Objective To study the changing of vertebral body marrow fat （raction（FF） in different age and sex and the relationship between FF and bone mineral densities（BMD）. Methods Eighty--five healthy volunteers aged from 21 to 70 years old and twenty patients with osteoporosis based on T score after dual X--ray absorptionmetry examination underwent proton magnetic resonance spectroscopy （ MRS ） in L3 vertebral bodies . The volunteers were divided into five groups according to the age（10 years and 16-18 cases in each group）. Results The FF values in 21-30 years group,31-40 years group,41-50 years group,51-60 years group , 〉60 years group and the osteoporotic group were 30.7% ± 4.4% , 35.5% ± 6.8% , 41.9%±6.6% , 46.8%± 5.5%, 51.7%±5.2% and 59.2%±7.4%, respectively. The FF values in L3 vertebral bone marrow in men were high than that in women in the same age group （P〈0.05） except 〉60 years group. There was negative correlation between marrow fat content and T score in osteoporotic group（γ=-0.6, P〈0.01）. Conclusion The vertebral marrow fat content in healthy adults was significantly increased with the aging. MRS may he used as a new way to evaluate the physiological and pathological process of bone marrow.

关 键 词：磁共振波谱学 骨髓 脂肪含量 

分 类 号：R445.2[医药卫生—影像医学与核医学] R322.71[医药卫生—诊断学]