鸡矢藤环烯醚萜苷对大鼠的长期毒性试验研究  

Long term toxicity test of iridiod glycosides from Paederia Scandens

作　　者：庞明群[1] 王双苗[1] 颜海燕[2] 胡才彪[1] 金辉[1] 周兰兰[1] 

机构地区：[1]安徽医科大学药理教研室,合肥230032 [2]军事医学科学院放射与辐射医学研究所,北京100850

出　　处：《安徽医科大学学报》2010年第1期62-65,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省科技攻关重点项目(编号:07010302176)

摘　　要：目的观察大鼠长期口服鸡矢藤环烯醚萜苷(IGPS)所产生的毒性反应及停药后恢复情况,为临床应用提供理论和实验依据。方法IGPS分别按280、700、1750mg/kg剂量给大鼠连续灌胃给药12周,分别相当于推荐人临床拟用剂量的40、100、250倍。观察给药期间及停药后2周大鼠的一般状况、体重变化、血液学指标、血液生化学指标、脏器系数和组织病理学等方面的变化。结果IGPS连续灌胃给药12周,除高剂量组红细胞数量有一过性短暂升高外,余各剂量组的大鼠体重、血液学指标、血液生化学指标、脏器系数及各组织器官的病理形态与对照组比较均未见明显异常改变;停药2周后,各项检查均正常。结论IGPS长期大量口服,对大鼠无明显损害。Objective To observe the long-term toxicity of the iridiod glycosides from Paederia Scandens（IGPS）and the recovery after drug withdrawal of long-term oral IGPS rats,provide theoretical and experimental evidence for clinical applications.Methods During treated with 280,700 and 1 750 mg/kg of IGPS for a successive course of 3 months through oral administration,which was equal to about 40,100,250 times clinical dosage.We observed the general state,weight variety,hematological indicators,routine blood biochemistry,and the pathological changes of tissues and organs,and also these changes 2 weeks after delivery withdrawal.Results IGPS continuous oral administration of 3 months,there were no evident effect in weight variety,hematological indicators,routine blood biochemistry,visceral index and pathological changes of every tissues and organs compared with those of control group,in addition to the high dose group,the numbers of red blood cells had a transient increase in short-term.The examination results of every item were normal after discontinuation 2 weeks.Conclusion A large number of long-term oral IGPS,which has no significant damage in rats.

关 键 词：鸡矢藤/药理学 大鼠 

分 类 号：R965.3[医药卫生—药理学] R282.71[医药卫生—药学]