AFU、TC在恶性腹水和非结核良性腹水鉴别诊断中的价值  

The value of L-fucosidase and total cholesterol in differential diagnosis of malignant and non-tuberculous benign ascites

作　　者：朱郁飞[1] 李峰[1] 许可银[1] 张弘[1] 

机构地区：[1]南通大学附属医院消化病科,226001

出　　处：《江苏医药》2010年第4期394-396,共3页Jiangsu Medical Journal

摘　　要：目的探讨α-L-岩藻糖苷酶(AFU)和总胆固醇(TC)在恶性腹水和非结核性良性腹水鉴别诊断价值。方法应用半自动生化分析仪对221例腹水进行AFU活性和TC测定。结果恶性腹水AFU和TC为(173.89±92.40)μmol.L-1.h-1和(1.69±0.98)mmol/L,明显高于非结核性良性腹水的(103.07±57.11)μmol.L-1.h-1和(0.70±0.60)mmol/L(P<0.01)。以AFU120μmol.L-1.h-1和TC1.1mmol/L为界值,恶性腹水的敏感性分别为67.65%和75.63%,特异性分别为72.55%和85.71%;两项联合检测的敏感性、特异性为77.45%、91.59%。结论腹水AFU、TC的活性测定有助于恶性腹水和非结核性良性腹水鉴别诊断;两者联合检测可提高鉴别诊断的敏感性和特异性。Objective To study the value of α-L-fucosidase（AFU）and total cholesterol（TC）in the differential diagnosis of malignant ascites and non-tuberculous benign ascites.Methods The AFU and TC of peritoneal fluid were tested by semi-automatic biochemistry analyzer in 221 cases.ResultsIn the malignant ascites,the activity levels of AFU and TC were（173.89±92.40）μmol· L-1·h-1 and（1.69±0.98）mmol/L,respectively,which were significantly higher than（103.07±57.11）μmol·L-1·h-1 and（0.70±0.60）mmol/L in the benign ascites（P0.01）.Taking 120 μmol· L-1·h-1 as the cut-off value for AFU and 1.1 mmol/L for TC in the malignant ascites,the sensitivites for AFU and TC were 67.65% and 75.63% and the specificities for AFU and TC were 72.55% and 85.71%,respectively.The sensitivity and specificity with combination test of two markers were 77.45% and 91.59%,respectively.Conclusion Determination of AFU and TC in the ascites is helpful in the differential diagnosis of malignant and non-tuberculous benign ascites.Simultaneous detection of AFU and TC can improve the sensitivity and specificity in the differential diagnosis.

关 键 词：Α-L-岩藻糖苷酶 总胆固醇 腹水 鉴别诊断 

分 类 号：R442[医药卫生—诊断学]