CRF R1受体拮抗剂对幼年大鼠快眼动睡眠的影响  

Effects of crf receptor antagonist on rem sleep in neonatal rat

作　　者：刘学东[1] 樊红琨[1] 张桂红[1] 王书春[1] 张朝[2] 冯平福[1,3] 

机构地区：[1]郑州大学基础医学院生理学教研室,河南郑州450001 [2]南京师范大学生命科学院江苏省分子医学生物技术重点实验室,江苏南京210046 [3]Case Western Reserve大学医学系呼吸、急诊与睡眠医学科,美国俄亥俄州克里夫兰44106

出　　处：《中国应用生理学杂志》2010年第1期86-89,共4页Chinese Journal of Applied Physiology

基　　金：河南省创新人才工程项目(20040001)

摘　　要：目的:观察腹腔注射CRFR1受体拮抗剂NBI27914对幼年大鼠睡眠/觉醒周期的影响。方法:生后13d的大鼠行电极安装术,术后12h开始多导睡眠描记,描记的第6h分别给予腹腔注射不同剂量的NBI27914、阿托品和等量生理盐水。结果:与基础水平相比,腹腔注射任何剂量NBI27914使幼年大鼠快眼动(REM)睡眠均显著减少,同时伴随着非快眼动(NREM)睡眠的增加,而生理盐水组无显著变化;阿托品组的大鼠REM睡眠也显著减少,伴随的是觉醒的增加。结论:阻断CRFR1受体可以剥夺幼鼠的REM睡眠。Objective：To observe the role of NBI27914,a CRF R1 receptor antagonist,in the regulation of neonatal sleep/wake cycle.Methods：Rat pups were surgically implanted with electrodes at postnatal day（PN） 13.At PN 14,6 hours polysomnographic recording data were continuously collected before and after administration of various doses of NBI 27914,atropine and the same amount of saline.Results：Compared with baseline,rapid eye movement（REM） sleep was significantly reduced and was replaced primarily by non-REM（NREM） sleep in all groups treated with NBI,but not with dimethyl sulfoxide/saline.Atropine suppressed REM sleep significantly and increased wakefulness simultaneously.Conclusion：Blockage of corticotropin-releasing factor（CRF） R1 receptors deprives neonatal rat REM sleep.

关 键 词：幼年大鼠 NBI27914 CRF REM睡眠 

分 类 号：R338.63[医药卫生—人体生理学]