冠心病患者血清OPG、sRANKL变化与冠脉病变程度的关系  

Correlative study on the relationship between serum OPG and sRANK and coronary artery lesions in patients with coronary heart disease

作　　者：王丽蕊[1] 李凌[1] 陈雅丽[1] 董文杰[1] 车丽玲[1] 肖莉丽[1] 

机构地区：[1]郑州大学第一附属医院,郑州450052

出　　处：《山东医药》2010年第5期7-8,共2页Shandong Medical Journal

基　　金：河南省教育厅自然科学研究计划项目(2009A320025)

摘　　要：目的探讨冠心病(CHD)患者血清骨保护素(OPG)、可溶性核因子κB受体活化因子配基(sRANKL)水平与冠脉病变程度的关系。方法选择心内科就诊患者80例,冠脉造影显示CHD 53例,其中单支病变组9例、双支病变组17例、多支病变组27例,正常对照组27例;采用ELLSA法检测各组血清OPG、sRANKL,并分析血清OPG、sRANKL水平与冠脉病变程度的相关性。结果与对照组比较,CHD患者血清OPG明显升高,且随冠脉病变程度增加而逐渐升高(P<0.05);血清sRANKL明显降低,且随冠脉病变程度增加而逐渐降低(P<0.05)。结论CHD患者血清OPG升高、sRANKL降低,二者可作为CHD的预测因子,血清OPG水平与冠脉病变程度有关。Objective To observe the serum osteoprotegerin（OPG）,receptor activator of soluble nuclear factorκB ligand（sRANKL） levels in patients with coronary heart disease,and to analyze the relationship between those parameters and the degree of coronary stenosis.Methods Eighty cases of coronary heart disease visited the Cardiology Department were included.Patients were divided into 3 groups according to the results of coronary angiography： single-vessel group（9 cases）,double-vessel group（17 cases）,more than three-vessel group（27 cases） and normal control group（27 cases）.The serum concentrations of OPG and sRANKL from the elbow vein were determined by ELISA.And to analyse the correlation between serum OPG and sRANKL and coronary artery lesions.Results Compared with normal control group,serum OPG levels was significantly higher（P〈0.05）.With the increase of lesions in branches of coronary artery,level of serum OPG gradually increased（P〈0.05）,serum sRANKL levels was significantly lower and the level of serum sRANKL gradually decreased（P〈0.05）.Conclusions In patients with coronary heart disease,serum OPG level was higher and serum sRANKL level is lower,which may be important in prediction of coronary heart disease.And the extent of serum OPG and sRANKL alterations are correlated with the severity of coronary artery lesions.

关 键 词：冠状动脉疾病 骨保护素 核因子κB受体活化因子配基 

分 类 号：R541.4[医药卫生—心血管疾病]