扩张型心肌病患者外周血CD_4^+CD_(25)^+ T细胞变化及临床意义  

Significance of the change of CD_4^+CD_(25)^+ T cells in patients with dilated cardiomyopathy

作　　者：吴海[1] 廖钦晨[1] 贺慧娟[1] 陈世德[1] 文宏[1] 刘艳丽[1] 

机构地区：[1]广西医科大学第一附属医院,南宁530021

出　　处：《山东医药》2010年第5期9-10,共2页Shandong Medical Journal

基　　金：广西自然科学基金资助项目(0640108)

摘　　要：目的探讨扩张型心肌病(DCM)患者外周血CD4+CD2+5T细胞变化及临床意义。方法采用流式细胞分析法检测30例DCM患者(DCM组)及20例健康者(对照组)的外周血CD4+CD2+5T细胞。结果外周血CD4+CD2+5T细胞占CD4+T细胞的比例DCM组为(8.53±1.64)%,对照组为(11.4±2.17)%,两组比较有统计学差异(P<0.01);且DCM患者心功能越差,CD4+CD2+5T细胞占CD4+T细胞的比例越低。结论DCM患者CD4+CD2+5T细胞比例减少,可能打破自身免疫耐受,发生针对心肌抗原的免疫反应,参与DCM发病。Objective To explore the significance of the change of CD＋4CD＋25T cells in peripheral blood in patients with dilated cardiomyopathy（DCM）.Methods The frequencies of CD＋4CD＋25T cells were detected in 30 patients with DCM（DCM group） and 20 healthy donors（control group） by flow cytometry.Results The ratio of CD＋4CD＋25T cells/CD＋4T cells was found to be significantly lower in DCM group[（8.53±1.64）%] than those of control group [（11.4±2.17）%]（P〈0.01）.The ratio of CD＋4CD＋25T cells/CD＋4T cells had negative correlation with New York heart association functional classification.Conlusion The decreased ratio of CD＋4CD＋25T cells/CD＋4T cells may lead to the down-regulation of autoimmune tolerance and brings about immunoreaction aiming directly at myocardium,which participates in the genesis of DCM.

关 键 词：扩张型心肌病 CD4+CD25+ 自身免疫 

分 类 号：R542.2[医药卫生—心血管疾病]