颅脑创伤后外周血白细胞的动态变化及意义  

Dynamic changes of WBC in the peripheral blood of traumatic brain injury patients and its significance

作　　者：高剑峰[1] 郭新宾[1] 陈心[1] 刘丽[1] 张建宁[1] 

机构地区：[1]天津医科大学总医院,天津300052

出　　处：《山东医药》2010年第9期1-3,共3页Shandong Medical Journal

摘　　要：目的研究颅脑创伤(TBI)后不同时间患者外周血白细胞(WBC)的动态变化规律及其临床意义。方法测定77例TBI患者伤后不同时间点外周血WBC的动态变化,分析WBC变化的影响因素。结果重型组受伤后第1、4、7天的WBC明显高于轻型组;感染组整体变化趋势明显高于无感染组,且第7、14天WBC与无感染组比较均有统计学差异(P均<0.01);病情恶化组第1、4、7、14天的WBC均明显高于治疗好转组(P<0.05或<0.01)。结论WBC的早期升高与伤情有关;伤后4 d内WBC升高不能作为判定是否感染的指标,伤后1～2周仍持续升高者可作为判定感染的指标之一;伤后1周内WBC明显升高者预后较差,反之预后较好。Objective To investigate the dynamic change and significance of white blood cells（WBC） in the peripheral blood of patients suffered from traumatic brain injury（TBI）. Methods The WBC of 77 patients with TBI were detected in the day 1 day 4 day 7 day 14 and day 21 after TBI. The influence factors of WBC change were analyzed. Results The number of WBC in the heavy TBI was significantly higher than that of mild TBI. The whole changing tendency and the number of WBC at day 7 and 14 after injury in infection group were significantly higher than those in non-infection group. In addition, the number of WBC in aggravation group was notably higher than that of WBC in improvement group. Conclusions The rise of WBC is related with traumatic condition in the earlier stage. The rise of WBC within 4 d can not be regard as the indicator for infection, the continuous rise of WBC in the 1-2 week after injury can be regarded as the indicator for infection. The patients with the rise of WBC within 1 week have a had prognosis and vice versa.

关 键 词：颅脑损伤 白细胞 动态变化 

分 类 号：R651.1[医药卫生—外科学]