无聚合物与聚合物紫杉醇涂层支架治疗冠心病的临床对比研究  

Comparsion of polymer-free paclitaxel-eluting stents and TAXUS stents in treating patients with coronary artery disease

作　　者：白明[1] 张福[2] 李强[1] 潘明[1] 汪涛[1] 药素毓[1] 黄晏[1] 张钲[1] 

机构地区：[1]兰州大学第一医院心内科,730070 [2]兰州大学第一临床医学院

出　　处：《中国介入心脏病学杂志》2010年第1期13-15,共3页Chinese Journal of Interventional Cardiology

摘　　要：目的比较无聚合物紫杉醇支架(垠艺)与聚合物紫杉醇涂层支架(TAXUS)用于冠心病患者的安全性及有效性。方法回顾分析兰州大学第一医院心脏中心置入垠艺支架治疗的75例冠心病患者和置入TAXUS支架治疗的59例冠心病患者,对比分析两组患者术后1年内主要不良心脏事件(MACE,包括心源性死亡、再发心绞痛或非致死性心肌梗死、再次靶血管血运重建)发生率、支架内血栓事件的发生率。结果两组除高血压例数外,在基本临床情况(包括年龄、性别、糖尿病、高脂血症、急性心肌梗死、不稳定型心绞痛、急性冠状动脉综合征、稳定型心绞痛)、冠状动脉病变特征(分叉病变、开口病变、三支病变、慢性完全闭塞病变、小病变、长病变、B2+C型病变)及基本介入技术指标(靶血管狭窄程度、病变长度、平均支架管径、平均支架长度)等方面差异均无统计学意义(P均>0.05);两组手术操作成功率均为100%,术后随访1年,主要心脏不良事件发生率垠艺组为5.6%,TAXUS组为7.0%,两组比较差异无统计学意义(P>0.05);TAXUS组支架内血栓1例,而垠艺组术后无支架内血栓事件发生,但两组比较差异无统计学意义(P>0.05)。结论无聚合物紫杉醇支架(垠艺支架)治疗冠心病安全有效,与TAXUS支架相比无明显差异。Objective To compare the safety and efficacy of polymer-free paclitexel-eluting stents （YINYI stents） and durable polymer TAXUS stents in the treatment of coronary artery disease.Methods The study included 75 patients who had received YINYI stents implantation and another 59 patients who had implanted with the TAXUS stents during the same period of time. All the patients were followed up for 12 months and their incidence of MACE （cardiac death,repeat angina pectoris and myocardial infarction,target vessel revascularization） and stent thrombosis were recorded.Results Baseline clinical data and angiography characteristics were similar between the 2 groups.The incidence of MACE at one-year follow-up was 5.63% in the YINYI group and 7.02% in the TAXUS group with no significant statistical difference （P0.05）.Stent thrombosis occurred only in 1 patient （1.75%） in the TAXUS group but no stent thrombosis was found in the YINYI group and there was no significant statistical difference between the 2 groups （P0.05）.Conclusion Implantation of the YINYI stent in patients with coronary artery disease is as safe and effective as the TAXUS stents in one-year clinical outcomes.

关 键 词：冠状动脉疾病 支架 血管成形术 经腔 经皮冠状动脉 

分 类 号：R543[医药卫生—心血管疾病]