正常健康人群外周血液中OPG和sRANKL浓度测定  

Concentration measurement of the OPG and sRANKL of peripheral blood among normal healthy people

作　　者：朱亮亮[1] 包倪荣[1] 周利武[1] 郭亭[1] 曾晓峰[1] 赵建宁[1] 

机构地区：[1]南京大学医学院临床学院南京军区南京总医院骨科,江苏南京210002

出　　处：《中国骨伤》2010年第2期87-89,共3页China Journal of Orthopaedics and Traumatology

基　　金：全军"十一五"重点攻关项目基金(编号:06G043)

摘　　要：目的:对正常健康人群外周血液中骨保护素(Osteoprotegerin,OPG)、核因子kappaB受体活化因子配体(receptor activator of NFκBligand,RANKL)浓度测定,明确其与年龄、性别之间是否存在一定关系。方法:收集220例正常健康人的清晨外周血液,其中男108例,女112例;年龄35～70岁,平均52.5岁。用ELISA法测血清中OPG、sRANKL浓度。结果:在35～70岁正常健康人群外周血液中的OPG、sRANKL浓度:女性,OPG21.95～315.47pg/ml,sRANKL10.25～370.20pmol/L;男性,OPG14.78～192.55pg/ml,sRANKL9.25～300.32pmol/L。46岁后女性血液中OPG浓度与年龄存在正相关;57岁后女性血液中sRANKL浓度明显升高。结论:年龄和性别影响外周血液中OPG、sRANKL浓度。46岁后女性血液中OPG浓度随年龄增加而升高,女性血液中sRANKL浓度57岁后明显升高。Objective：To measure the concentration of osteoprotegerin （OPG） and receptor activator of NF κB ligand （sRANKL） in peripheral blood among normal healthy people and investigate the relationship pf the concentration with age and sex. Methods：The peripheral blood samples of 220 normal healthy people （included 108 males and 112 females,aged from 35 to 70） were collected in the morning. The OPG and sRANKL concentration of blood serum were measured by ELISA. Results： The concentrations in female peripheral blood were：OPG 21.95 to 315.47 pg / ml,sRANKL 10.25 to 370.20 pmol / L;while in male were：OPG 14.78 to 192.55 pg / ml,sRANKL 9.22 to 300.32 pmol / L. There was positive correlation between the OPG concentration and age in the females older than 46 years. And for female older than 57,the sRANKL concentration of peripheral blood increases obviously. Conclusion：Age and sex are the elements that affect the OPG and sRANKL concentration in peripheral blood. For female older than 46,the OPG concentration of peripheral blood increases with age,while the sRANKL concentration of peripheral blood increases for females older than 57.

关 键 词：骨保护素 核激活因子受体配体 浓度测定 外周血 健康人 

分 类 号：R979.7[医药卫生—药品]