银杏内酯B衍生物对血栓形成的抑制作用  

Inhibitory Effect of Ginkolide B Derivative on Thrombogenesis

作　　者：崔姣[1] 潘苏华[1] 刘成鼎[1] 许惠琴[1] 

机构地区：[1]南京中医药大学药理教研室,江苏南京210046

出　　处：《广州中医药大学学报》2010年第2期143-146,共4页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：江苏省中医药局科研项目(编号:H-024)

摘　　要：【目的】观察银杏内酯B衍生物(XQ)对实验性血栓形成的影响。【方法】选用SD雄性大鼠随机分为模型对照组,曲克芦丁组(剂量为48 mg.kg-1.d-1),银杏内酯B(GB)组(剂量为7.8 mg.kg-1.d-1),XQ低、中、高剂量组(剂量分别为3.9、7.8、15.6 mg.kg-1.d-1)。分别采用颈动—静脉旁路法复制血栓模型及电刺激法复制混合血栓模型,观察XQ对血栓形成的影响。选用ICR雄性小鼠随机分为模型对照组,曲克芦丁组(剂量为96 mg.kg-1.d-1),GB组(剂量为15.6 mg.kg-1.d-1),XQ低、中、高剂量组(剂量分别为7.8、15.6、31.2 mg.kg-1.d-1)。采用5-腺苷二磷酸二钠盐(ADP)致小鼠急性肺血栓模型,观察XQ对血栓形成的影响。【结果】XQ中、高剂量组均能显著减轻大鼠动脉血栓的湿、干质量(与模型对照组比较,P<0.05或P<0.01),显著延长大鼠混合血栓形成时间(与模型对照组比较,P<0.05)。XQ高剂量组对小鼠急性肺血栓形成有抑制作用,并可显著缩短小鼠的喘促持续时间(与模型对照组比较,P<0.05)。【结论】XQ具有一定的抗血栓形成作用。Objective To observe the effect of ginkolide B derivative （XQ） on animal thrombosis. Methods SD male rats were randomized into the model group, troxerutin （48 mg·kg^-1·d^-1 ） group, ginkolide B （7. 8 mg·kg^-1·d^-1） group, and low-, middle- and high-dose XQ （in the dose of 3.9, 7.8 and 15.6 mg ·kg^-1·d^-1 respectively） groups. The anti-thrombotic effect of XQ was observed on rats mixed thrombosis model induced by arterio-venous shunt method and electrical stimulation. Meanwhile, ICR male mice were randomized into the model group, troxerutin （96 mg ·kg^-1·d^-1） group, ginkolide B （15.6 mg·kg^-1·d^-1） group, and low-, middle-and high-dose XQ （in the dose of 7.8, 15.6 and 31.2 mg·kg^-1·d^-1respectively） groups. The anti-thrombotic effect of XQ was also observed on mice acute pulmonary embolism model induced by adenosine diphosphate （ADP）. Results XQ at the dose of 7. 8 and 15.6 mg·kg^-1·d^-1 decreased the dry and wet weight of the thrombosis, and obviously prolonged the formation time of rats carotid artery thrombosis as compared to the model group （P 〈 0.05 or P 〈0. 01）. XQ in the dose of 31.2 mg·kg^-1·d^-1 shortened dyspnea duration in mice with acute pulmonary embolism （P 〈 0. 05 compared to the model group）. Conclusion XQ has certain antithrombotic effect.

关 键 词：银杏内酯B衍生物/药理学 血栓形成/中药疗法 疾病模型 动物 大鼠 小鼠 

分 类 号：R285.5[医药卫生—中药学]