戊乙奎醚预防腹腔镜胆囊切除术后恶心呕吐的效果  

Effect of penehyclidine hydrochloride in the prevention of nausea and vomitting after laparoscopic cholecystectomy

作　　者：张治明[1] 欧阳帆[1] 刘琦[1] 李松林[1] 

机构地区：[1]郴州市第一人民医院,湖南郴州423000

出　　处：《海南医学》2010年第6期33-34,共2页Hainan Medical Journal

基　　金：郴州市第一人民医院资助科研项目(编号:2009-012)

摘　　要：目的观察戊乙奎醚预防腹腔镜胆囊摘除术后恶心呕吐的效果。方法将60例ASAI-II年龄25-53岁计划在全身麻醉下进行腹腔镜手术的病人随机分为两组:P组在麻醉前使用戊乙奎醚0.02mg/kg肌肉注射,C组使用相当容量的生理盐水肌肉注射。记录术后的6h(T1),12h(T2),24h(T3),48h(T4)病人恶心呕吐的VSS评分,并对各个时段出现呕吐症状的病例计数。结果在T1-2P组术后恶心呕吐的VSS评分明显低于C组(P<0.05),而T3-4差异没有统计学意义;两组均有呕吐的病例发生,C组主要集中在前12h,P组则在12h后有部分病例出现;P组总数明显低于C组(P<0.05)。结论麻醉前使用戊乙奎醚能预防腹腔镜胆囊切除术后恶心呕吐,前12h效果明显。Objective To observe the effect of peneyclidine hydrechloride in the prevention of post operation nausea and vomitting（PONV） of laparoscopic cholecystectomy （LC）. Methods Sixty patients scheduled for laparoscope cholecystectomy undergoing general anesthesia were allocated to two group： Patients were injected with panehyclidine hydrochloric at the dosage of 0.02 mg/kg before anesthesia induction （ Group P） ; and others with 0. 9% sodium chloride（ Group C）. Visual simulation scale（VSS） were used to assess PONV, and VSS were recorded at 6h（T1 ）, 12h（T 2）, 24h（ T3 ）, 48h （T4） after operation. And the patients who have vometted were counted at durationof0-6h,6-12h, 12-24h,24-48h. Results （1） Compared with Group C , VSSatT1＆T2inGroup P was signifieanfly lower, while there were no difference at T3 ＆ T4 ; （2）There were several vomitting eases in Both Group P and C, and most of them were occurred at the first 12 after operation, the number of vomitting case in Group P was significantly less than that in Group C. Conclusion Before anesthesia, penahyclidine hydrochloride can effectively prevent PONV of LC.

关 键 词：腹腔镜胆囊切除术 并发症 恶心呕吐 戊乙奎醚 

分 类 号：R657.4[医药卫生—外科学]