硝基苯酰基硫脲衍生物的合成与生物活性研究  

Synthesis and biological activity of nitrobenzoyl naphthalene acyl thiosemicarbazides

作　　者：柳文敏[1] 王宏伟[1] 惠丰立[2] 周桂平[1] 王倩[1] 

机构地区：[1]南阳师范学院化学与制药工程学院,河南南阳473061 [2]南阳师范学院生物与生命科学学院,河南南阳473061

出　　处：《化学研究与应用》2010年第3期343-346,共4页Chemical Research and Application

基　　金：河南省教育厅自然科学研究项目(200913150020);南阳师范学院2006年专项资助项目(nytck009)

摘　　要：酰氨基硫脲类化合物具有很好的生物活性，如消炎、抗菌、抗结核、抗癌、杀菌、杀虫及植物生长调节等，也是重要的有机合成中间体。因此，随着新型农药的开发研究，酰氨基硫脲类化合物又成为药物开发的热点之一。Three nitrobenzoyl naphthalene aeyl thiosemicarbazides（ Ⅱa -Ⅱc）were synthesized by addition reaction of naphthalene acyl hydrazines with nitrophenyl isothiocyanates, which were obtained by the reaction of potassium thiocyanate with nitrobenzoyl chloride. The structures of the products were characterized by 1H NMR, IR and elemental analysis. The preliminary biological activity test indicated that the synthesized compounds could promote the growth of paddy root at the concentration of ling/L, the compounds of Ⅱa - Ⅱc had antibacterial activity against B. subtilis.

关 键 词：酰氨基硫脲 芳基酰肼 Α-萘乙酸 合成 生物活性 

分 类 号：O625.7[理学—有机化学]