关于新药免疫毒性研究中大鼠品系选择的探讨  

Discussion about Rat Strains Selection in the Study of Drug-Induced Immunotoxicity

作　　者：李秀芳[1] 金若敏[1] 

机构地区：[1]上海中医药大学药物安全性评价研究中心,上海201203

出　　处：《医学综述》2010年第6期811-813,共3页Medical Recapitulate

基　　金：国家十一.五科技支撑计划项目(2006BAI06A03-02);国家"重大新药创制"科技重大专项项目(2009ZX0902-002)

摘　　要：新药研发过程中,药物诱导的免疫毒性是导致药物最终被淘汰的重要原因之一,对药物的免疫毒性作出预测至关重要。大鼠是药物免疫毒性研究最常用的实验动物,不同品系的大鼠对药物的免疫毒性敏感性存在着较大差异,文章从不同品系大鼠机体1型辅助T淋巴细胞/2型辅助T淋巴细胞分布格局的极化差异入手,介绍了新药免疫毒性研究中对大鼠品系选择的依据。Drug-induced immunotoxicity is one of the most important causes of drug withdrawal during drug development. Prediction of drug-induced immunotoxicity is very important in the pre-clinical studies. And rat is one of the most useful models in the process. Previous studies have shown that different rat strains vary in their susceptibility to the immunotoxicity of the same drug. In this paper, the Th1/Th2 distribution pattern of different rat strains were reviewed. And the rat strains selection basis in the drug-induced immunotoxicity studies was introduced.

关 键 词：免疫毒性 大鼠 品系 

分 类 号：R965.3[医药卫生—药理学]