细胞色素P450介导的第二代抗抑郁药的药物相互作用  

Interactions of the Second-Generation Antidepressants Mediated by Cytochrome P450

作　　者：赵莹莹[1] 林凌云[1] 

机构地区：[1]汕头大学精神卫生中心,汕头515063

出　　处：《医学综述》2010年第6期940-943,共4页Medical Recapitulate

摘　　要：第二代抗抑郁药主要在肝脏经细胞色素P450(CYP450)酶代谢,并且不同程度地对CYP450酶产生抑制,因此该类药物与其他经肝脏CYP450酶代谢的药物合用时会相互作用,并进而影响治疗药物的血药浓度。本文对国内外近年来第二代抗抑郁药与其他精神科中常见的药物合用时产生的相互作用予以综述。The second-generation antidepressants are metabolized in liver by the cytoehrome 17450 （CYP450）enzyme system. These drugs can inhibit the CYP isozymes to different extent so as to affect the blood concentration of other drugs. This article reviewed the clinically relevant pharmacokinetic drug interactions between the second-generation antidepressants and other common drugs for mental diseases in clinical experiences.

关 键 词：抗抑郁药 药物相互作用 细胞色素P450 药物代谢 

分 类 号：R96[医药卫生—药理学]