Using Gamma-Radiation for Drug Releasing from MWNT Vehicle  

作　　者：李俊 孙浩 戴耀东 

机构地区：[1]College of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Nan.ring 210016

出　　处：《Chinese Physics Letters》2010年第3期297-299,共3页中国物理快报（英文版）

摘　　要：A drug delivery system via multi-walled carbon nanotube （MWNT） vehicle was synthesized in aqueous solution. MWNTs were first noncovalently functionalized with chitosan oligomers （CS） with a molecule weight of 4000-6000, making MWNTs water-soluble, and then a cancer ancillary drug tea polyphenols （TP） was conjugated mainly via the hydrogen bond between CS and TP molecules, making MWNTs efficient vehicle for drug delivering. The release of drug molecules can be realized by pH variation and γ-radiation, leading to new methods for controlling drug release from carbon nanotubes carrier. Due to the high penetrability of γ-rays, γ-radiation shows up new opportunities in controlled drug release, possibly facilitating the future cancer treatment in vivo.A drug delivery system via multi-walled carbon nanotube （MWNT） vehicle was synthesized in aqueous solution. MWNTs were first noncovalently functionalized with chitosan oligomers （CS） with a molecule weight of 4000-6000, making MWNTs water-soluble, and then a cancer ancillary drug tea polyphenols （TP） was conjugated mainly via the hydrogen bond between CS and TP molecules, making MWNTs efficient vehicle for drug delivering. The release of drug molecules can be realized by pH variation and γ-radiation, leading to new methods for controlling drug release from carbon nanotubes carrier. Due to the high penetrability of γ-rays, γ-radiation shows up new opportunities in controlled drug release, possibly facilitating the future cancer treatment in vivo.

关 键 词：Soft matter liquids and polymers Atomic and molecular physics Fluid dynamics Medical physics Biological physics 

分 类 号：TQ460.4[化学工程—制药化工] TB383[一般工业技术—材料科学与工程]