Comments on the release Laboratory Manual for the Human Semen of the 5th edition of the WHO Examination and Processing of  

作　　者：W. C. L. Ford 

机构地区：[1]Obstetrics ＆ Gynaecology Unit, Clinical Science at South Bristol, University of Bristol, St Michael＇s Hospital, Bristol BS28EG, UK

出　　处：《Asian Journal of Andrology》2010年第1期59-63,共5页亚洲男性学杂志（英文版）

摘　　要：The authors of the World Health Organization Semen Analysis Manual are to be congratulated on producing a new edition; it is an essential tool to disseminate good practice in andrology. However, the tests described have poor prognostic power to predict a man＇s fertility and show little about the underlying causes of sub-fertility. This commentary urges a revival of research into the diagnosis of male fertility. It suggests that fertility should be regarded as a continuum and that the artificial binary division between fertile and infertile should be abandoned. Models to predict a sub-fertile couple＇s chance of conception in a year should be developed on the basis of prospective data. These models would allow for sophisticated decision making about management. The future lies in the identification of tests to detect underlying pathologies open to specific treatment. Leads such as oxidative stress, defects in the intracellular regulation and the developing field ofproteomics should be explored.The authors of the World Health Organization Semen Analysis Manual are to be congratulated on producing a new edition; it is an essential tool to disseminate good practice in andrology. However, the tests described have poor prognostic power to predict a man＇s fertility and show little about the underlying causes of sub-fertility. This commentary urges a revival of research into the diagnosis of male fertility. It suggests that fertility should be regarded as a continuum and that the artificial binary division between fertile and infertile should be abandoned. Models to predict a sub-fertile couple＇s chance of conception in a year should be developed on the basis of prospective data. These models would allow for sophisticated decision making about management. The future lies in the identification of tests to detect underlying pathologies open to specific treatment. Leads such as oxidative stress, defects in the intracellular regulation and the developing field ofproteomics should be explored.

关 键 词：diagnosis male infertility oxidative stress predictive value of tests sperm count 

分 类 号：R19[医药卫生—卫生事业管理] S858.235.1[医药卫生—公共卫生与预防医学]