人、猪和鸡血清中抗禽戊型肝炎病毒抗体的检测与鉴定  

DETECTION AND CHARACTERIZATION OF HUMAN,SWINE,DUCK AND CHICKEN SERUM ANTIBODIES AGAINST AVIAN HEPATITIS E VIRUS

作　　者：荆胜涛[1] 张红霞[2] 孙培明[1] 董施伟[1] 赵钦[1] 张璐[1] 周恩民[1] 

机构地区：[1]山东农业大学动物医学院山东省生物技术与疫病防治重点实验室 [2]山东农业大学校医院,山东泰安271018

出　　处：《山东农业大学学报（自然科学版）》2010年第1期89-92,共4页Journal of Shandong Agricultural University：Natural Science Edition

基　　金：山东省泰山学者基金;家畜疫病病原生物学国家重点实验室(中国农业科学院兰州兽医研究所)开放课题资助

摘　　要：通过对人、猪和鸡血清中的抗禽戊型肝炎病毒（hepatitis E virus,HEV）ORF2抗体的检测以及对阳性血清抗体特异性的鉴定,本研究结果表明,人、猪和禽血清中抗禽HEVORF2抗体阳性率为0.91%~62.5%。因为禽与哺乳动物HEV ORF2抗原具有共有的抗原表位,而阳性血清中抗禽HEV ORF2特异性抗原表位抗体的阳性率为41.3%~92.1%,提示人、猪和鸡都有感染禽HEV的可能性,这为进一步验证禽HEV可能造成的人兽共感染提供新的科学依据。This study described the serological investigation of avian hepatitis E by testing human,swine and chicken serum antibodies against avian hepatitis E virus（HEV） ORF2 and characterization of the serum antibody specificities.The results demonstrated that the positive rates of human,swine and chicken serum antibody against avian HEV ORF2 antigen were from 0.91% to 62.5%.Because avian and mammalian HEV ORF2 share common epitopes,and the positive rate of specific antibodies against avian HEV ORF2 epitopes were from 41.3% to 92.1%,these results suggested that human,swine and chicken could be infected by avian HEV and potential zoonosis of avian HEV.

关 键 词：戊型肝炎病毒 禽戊型肝炎病毒 禽戊型肝炎病毒特异性抗体 血清学调查 

分 类 号：S834[农业科学—畜牧学]