急性冠脉综合征应用小剂量辛伐他汀联合阿昔莫司降脂治疗的疗效观察  

Effects of Low-dose Simvastatin Combined with Acipimox on Acute Coronary Syndrome

作　　者：耿学藩[1] 张学功[1] 牛玉岭[1] 安永为[1] 

机构地区：[1]北京市房山区第一医院心内科,102400

出　　处：《中国全科医学》2010年第9期920-922,共3页Chinese General Practice

摘　　要：目的观察小剂量辛伐他汀联合阿昔莫司降脂治疗急性冠脉综合征(ACS)的疗效及安全性。方法选择156例ACS合并高脂血症患者,将患者随机分为4组:A组:辛伐他汀10mg/d,38例;B组:辛伐他丁联合阿昔莫司(辛伐他汀10mg/d、阿昔莫司750mg/d),40例;C组:辛伐他汀20mg/d,38例;D组:辛伐他丁联合阿昔莫司(辛伐他汀20mg/d、阿昔莫司750mg/d),40例。4组患者经上述药物及常规治疗,在治疗后12周观察调脂药物的疗效、肝肾功能损害等。结果4组患者治疗后,B、D组降低总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)以及升高高密度脂蛋白胆固醇(HDL-C)水平均优于C、A组,差异亦均有统计学意义(P<0.05),而D组与B组比较,差异有统计学意义(P<0.05),但不良反应明显增加。结论小剂量辛伐他汀联合阿昔莫司能有效地使LDL-C、TC达标,同时对降低TG、升高HDL-C也具有较好的效果,不良反应无明显增加。Objective To evaluate the efficacy and safety of low-dose simvastatin in combination with acipimox in treatment of the patients with acute coronary syndrome （ACS）.Methods One hundred fifty-six ACS patients with hyperlipidemia were divided randomly into groups A（n=38,receiving simvastatin 10 mg/d）,B （n=40,simvastatin 10 mg/d,acipimox 750 mg/d）,C （n=38,simvastatin 20 mg/d）,D （simvastatin 20 mg/d,acipimox 750 mg/d）.The efficacy of lipid-lowering and the liver,kidney dysfunction were observed 12 weeks after treatment.Results The reduced total cholesterol （TC）,low-density lipoprotein cholesterol （LDL-C）,triglycerides （TG）,and increased high-density lipoprotein cholesterol （HDL-C） were better in groups B,D than in groups C,A,the difference was significant （P〈0.05）,there was significant difference between groups D and B （P〈0.05）,but adverse reactions increased remarkably.Conclusion Low-dose simvastatin with acipimox can make effectively LDL-C,TC meet the standards,and reduce TG,elevate HDL-C,with fewer adverse reactions.

关 键 词：辛伐他汀 急性冠脉综合征 血脂异常 

分 类 号：R541[医药卫生—心血管疾病]