急性冠脉综合征患者血浆单核细胞趋化因子-1水平的相关研究  

Relationship of Level of Monocyte Chemotactic Protin-1 in Blood Plasm to Acute Coronary Syndrome

作　　者：杨立明[1] 许丹[1] 马威[1] 尚小明[1] 孙淑娴[1] 张春来[1] 纪征[1] 姜玉凤[1] 卢峰[1] 赵宝春[1] 张琦[1] 

机构地区：[1]河北医科大学附属唐山工人医院,河北省唐山市063000

出　　处：《中国全科医学》2010年第9期925-927,共3页Chinese General Practice

摘　　要：目的探讨急性心肌梗死与不稳定型心绞痛患者血浆单核细胞趋化因子-1(MCP-1)水平;以及不同部位急性心肌梗死患者MCP-1水平及其意义。方法87例急性冠脉综合征患者分为两组:急性心肌梗死组57例,不稳定型心绞痛组30例,经冠状动脉造影、心电图及心肌酶学证实;采用ELISA方法(在入院时,入院后第3天、第7天)检测血浆MCP-1水平。检测不同部位急性心肌梗死患者MCP-1水平,并比较有无差异。结果两组急性冠脉综合征患者血浆MCP-1水平在入院时,入院后第3天、第7天比较,差异均无统计学意义(P>0.05)。两组患者MCP-1水平达峰构成比比较,差异均无统计学意义(P>0.05)。不同部位急性心肌梗死患者MCP-1水平比较,差异均无统计学意义(P>0.05)。结论血浆MCP-1水平不能够准确判断急性冠脉综合征患者的类型及严重程度。急性心肌梗死与不稳定型心绞痛患者MCP-1水平达峰无差异。急性心肌梗死患者血浆MCP-1水平与梗死部位无关。Objective To investigate the level of plasma monocyte chemotactic factor-1 （MCP-1） in patients with acute myocardial infarction （AMI） or unstable angina pectoris （UAP） and the level of MCP-1 in AMI patients and to find their significance.Methods Eighty-seven acute coronary syndrome （ACS） patients were divided into groups AMI （n=57）,UAP （n=30）.The plasma MCP-1 level was determined by ELISA assay on days 3,7 after admission.Results There was not significant difference in plasma MCP-1 between 2 groups on admission,on days 3,7 after admission （P〉0.05）,or in component ratio of peak MCP-1 level （P〉0.05）,or in MCP-1 level between patients with AMI in different parts （P〉0.05）.Conclusion Plasma MCP-1 level can not diagnose accurately the types or severity of ACS.There is not difference in MCP-1 peak level between AMI and UAP patients.Plasma MCP-1 level is not related to infarct area in AMI patients.

关 键 词：急性冠脉综合征 急性心肌梗死 不稳定型心绞痛 单核细胞趋化因子-1 

分 类 号：R541.4[医药卫生—心血管疾病]