中国北方城市健康体检汉族人群代谢综合征新危险因素分析  

Analysis of New Risk Factors of Metabolic Syndrome in Han Population Receiving Physical Examination in Chinese Northern Cities

作　　者：陈思娇[1] 张浩[2] 常小丽[3] 付建平[3] 李红燕[1] 杨红艳[1] 郭英华[1] 魏敏[1] 王海龙[4] 宋今丹[5] 

机构地区：[1]中国医科大学附属第一医院干部医疗工作部老年医学研究室,辽宁省沈阳市110001 [2]中国医科大学附属第一医院体检中心 [3]中国医科大学 [4]中国医科大学附属第一医院临床流行病学教研室 [5]卫生部细胞生物学重点实验室中国医科大学医学分子生物学研究所

出　　处：《中国全科医学》2010年第9期980-983,985,共5页Chinese General Practice

基　　金：辽宁省科技攻关项目(2007225004-3);辽宁省教育厅项目(2008818);沈阳市科学技术计划项目(1071162-9-00)

摘　　要：目的探讨新的心血管危险因素非酒精性脂肪肝病(non-alcoholic fatty liver disease NAFLD)和血管性勃起功能障碍(Erectile dysfunction,ED)与代谢综合征(MS)组分的关系。方法从2008—2009年北方城市健康体检人群中随机整群抽样18096例进行调查和血清学检查。采用SPSS13.0统计软件分析探讨新的心血管危险因素NAFLD和ED与MS各主要组分之间的关系。结果本次调查资料完整者共18096例,年龄18～76岁,平均(46.8±10.1)岁。男,10096例,占55.79%,;女,8000例,占44.21%。MS知晓率为8.33%;成年健康体检者MS的患病率为21.18%;MS最常见的组分依次是高尿酸血症、肥胖、高血压和血脂异常。MS及其各组分体质指数(BMI)和腰臀比(WHR)比较,BMI和WHR最高的组分是超重或肥胖、血管性ED、糖尿病前期和高血压;MS伴发NAFLD3721例,患病率为19.67%;以MS伴发NAFLD为因变量,Logistic回归分析结果:年龄、吸烟史、饮酒史等13个变量,差异均有统计学意义(P<0.01)。年龄、吸烟史、饮酒史、DM家族史、BMI、腰围及ALT升高为疾病的危险因素,体育锻炼和职业性体力劳动为其保护因素。血管性ED106例,患病率为1.04%;以MS伴发ED为因变量,Logis-tic回归分析结果:年龄、文化程度、体育锻炼等8个变量,差异均有统计学意义(P<0.01)。年龄、DM家族史、BMI和腰围为疾病的危险因素,文化程度、体育锻炼和职业性体力劳动为其保护因素。结论MS新的心血管危险因素包括NAFLD和ED,它们均与MS各组分间关系密切,可能成为MS的组分;对新的心血管危险因素的控制,为心脑血管疾病的预防提供了新途径。Objective To study the relationship of new cardiovascular risk factors of non-alcoholic fatty liver disease （NAFLD） and vascular erectile dysfunction （ED） to metabolic syndrome （MS） component.Methods An investigation was conducted by stratified cluster sampling to perform serological examination in 18096 healthy subjects receiving physical examinations in northern cities from 2008 to 2009.SPSS13.0 was used to analyze the relationship of NAFLD,ED to the main components of MS.Results A total of 18,096 subjects （aged 18 to 76 years,averaging 46.8 ± 10.1 years old;10,096 males,accounting for 55.79%;8,000 females accounting for 44.21%） had integrated survey data.MS awareness rate was 8.33%.The MS prevalence was 21.18% in healthy adult subjects.The commonest components of MS were in turn hyperuricemia,obesity,hypertension,dyslipidemia.The highest components of BMI,WHR were overweight or obesity,vascular ED,pre-diabetes and hypertension.MS with NAFLD was noted in 3,721 subjects,with a prevalence of 19.67%.Taking MS with NAFLD as dependent variable,Logistic regression analysis showed that there was significant difference in 13 factors such as age,smoking and drinking history,etc.（P﹤0.01）.Age,smoking and drinking history,DM family history,BMI,waist circumference （WC） and elevated ALT were the risk factors,but physical activities and professional physical labor were protective factors.One hundred six cases had vascular ED,with a prevalence of 1.04%.Taking MS with ED as independent variable,Logistic regression analysis showed that there was significant difference in 8 factors such as age,educational level,physical activities etc.（P﹤0.01）.Age EM family history,BMI and circumference were risk factors,and educational level,physical activities and professional physical labor were protective factors.Conclusion The new cardiovascular risk factors includes NAFKD and ED,which are closely associated with MS and may become MS components.Control of new cardiovascular risk factors provides a new way to

关 键 词：代谢综合征 危险因素 脂肪肝 非酒精性 勃起功能障碍 

分 类 号：R541.6[医药卫生—心血管疾病]