肠功能恢复汤与东菱克栓酶预防术后肠粘连的实验研究  

Experimental Research on prevention of Postopertive Intestinal Adhesion with Decoction to Help Recovering Intestinal Function and TOBISHI DF 521

作　　者：王春荣[1] 张青山[1] 贾宗良[1] 孙学军[1] 徐寿武 

机构地区：[1]西安医科大学第一临床医学院

出　　处：《中国中西医结合外科杂志》1998年第6期340-343,共4页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

摘　　要：目的：观察中药肠功能恢复汤与东菱克栓酶预防术后腹腔肠粘连的效果及对切口愈合的影响。方法：采用Ｗｉｓｔａｒ大鼠７２只，双盲随机分组法分为四组，制成肠粘连模型。分为中药治疗组，腹腔注入东菱克栓酶组，中药治疗加腹腔注入东菱克栓酶组，并分别与对照组比较。结果：中药肠功能恢复汤、东菱克栓酶：①能明显降低腹腔内渗液纤维蛋白原的浓度，能加速纤维蛋白（原）的分解，②能明显减轻肠粘连的程度，以二药合用效果最好（Ｐ＜０．０１）。③对腹腔内脏器的缝合口及腹壁切口的愈合无不良影响。Objective:To observe the comparative effect on the prevention of the post operative intestinal adhesion and the healing of wounds with “Decoction to help Recovering Intestinal Function″ and TOBISHI 521.Methods:Seventy two wistat big mice were randomly divided into four groups and modeled intestinal adhesion. Three groups were respectively treated with①Chinese herbal decoction, ②TOBISHI DF 521 injected into the abdominal cavity,and ③both Chinese herbal decoction and TOBISHI 521.They were compared with the control group.Results:The combined use of herbal decoction and TOBISHI DF 521 could obviously decrease the concentration of the fibrinogen in abdominal exudate to accelerate the decomposition of the fibrinogen,and could evidently reduce the severity of adhesion .The combination proved to be the best choice,( P<0.01 ).In addition,the combined treatment did no harm to the healing of wounds on the abdominal organs and the abdominal wall. Conclusion:The combined use of the ″Decoction to Help Recovering Intestinal Function″ and TOBISHI DF 521 is a simple and effective method to prevent post operative intestinal adhesion.

关 键 词：肠功能恢复汤 东菱克栓酶 肠粘连 

分 类 号：R656.05[医药卫生—外科学]