咳嗽峰值流速在COPD机械通气患者撤机相关性研究  

Cough peak flow in COPD patients with mechanical ventilation weaning correlation

作　　者：卢树标[1] 吕文慧[1] 

机构地区：[1]广东省佛山市顺德区第一人民医院,528300

出　　处：《中国医学创新》2010年第9期6-8,共3页Medical Innovation of China

摘　　要：目的探讨咳嗽峰值流速能否预测COPD机械通气患者成功撤机。方法前瞻性采集19例进行机械通气的重度COPD患者通过自主通气治疗后准备拔除气管捕管前的咳嗽峰值流速，肺功能指标，APACHE Ⅱ，根据最终撤机结果将患者分成两组，采用U检验，Х^2检验，ROC曲线进行分析。结果两组患者CPF有显著性差异（P〈0．05），根据咳嗽峰值流速推测撤机成功所作ROC曲线下面积为0．917（P〈0．05），并确定最佳临界值为29．35L／min，以CPF=29．35 L／min捧测撤机成功率敏感性为66．7％，特异性为100％。结论咳嗽峰值流速在一定程度上可预测机械通气的COPD患者撤机的成功率。Objective To investigate whether the Cough Peak Flows can as a predictor of extubation outcome of the patients with severe COPD. Methods Prospective study was performed among 19 patients with severe COPD. The clinical and physiological parameters were analyzed by Kruskal - Wailis/Mann - Whitney tests, Х^2 tests and ROC. Results Kruskal - Wallis/Mann - Whitney tests revealed significant differences about Cough Peak Flows between two groups （ P 〈 0.05 ）. based on the results of ROC, In the areas under the receiver operating characteristics curves （AUC） was 0. 917 ,The optimal operating point of Cough Peak Flows was 29. 35 L/ruin, the sensitivity and specificity were66. 7 % vs l00%, （ P 〈0.05 ）. Con- clusion These data suggest that cough strength, measmed objectively, is a predictor of extubation outcome.

关 键 词：咳嗽峰值流速 慢性阻塞悱肺疾病 撒机 

分 类 号：R563.9[医药卫生—呼吸系统]