维生素E和人参茎叶皂甙对小鼠高脂血症的影响  

Effect of Vitamin E and Ginsenosides on Hyperlipidemia in Mice

作　　者：潘宇[1] 何陵湘[1] 宋湛萍 杨燕[2] 

机构地区：[1]广东省农垦中心医院药剂科,524002 [2]广东医学院药理教研室,524023

出　　处：《广东医学》1998年第12期899-900,共2页Guangdong Medical Journal

摘　　要：目的：探讨维生素E（VitE）和人参茎叶皂甙（GSL）对高脂血症小鼠血脂的影响。方法：用胆固醇乳剂灌胃小鼠10d，建立小鼠高脂血症模型，观察用VitE和人参茎叶甙后小鼠血脂水平的变化。结果：高脂模型组血清总胆固醇（TC）、甘油三酯（TG）升高，高密度脂蛋白胆固醇（HDL－C）降低，与对照组比较，差异有显著性，表明模型建立成功。与模型组比较，VitE可降低TG，升高HDL－C，而不降低TC。人参茎叶甙则只降低TC，升高HDL-C，而不降低TG。结论：VitE和人参茎叶皂甙对高脂血症小鼠均有一定降脂作用。Objective:To evaluate the effect of vitaminE(Vit E)and ginsenoside of stems and leaves(GSL) on hyperlipidemia in mice .Metods:Hyperlipidemia model was set up by feeding high cholesterol emulsion 10 days.The levels of serum lipid were measured.Results:Serum total cholesterol(TC)and triglyceride(TG)increased,high density lipoprotein cholesterol (HDL-C)reduced in hyperlipidemia model group.Vit E dectrased TG but increase HDL-C.and didn't reduce TC.However ,GSK decreased TC butincreased HKL-C,and didn't derease TG.Conclusion:Both Vit E and GSL have the effect of lowering serum lipid in hyperlipiidemia in mice to some extent

关 键 词：维生素E 人参茎叶皂甙 高脂血症 疾病模型 

分 类 号：R589.205[医药卫生—内分泌] R259.892[医药卫生—内科学]