α,β-不饱和羰基化合物中共轭碳碳双键的有机小分子选择性催化还原  

Selectively organocatalytic reduction of conjugate C=C bonds in α,β-unsaturated carbonyl compounds

作　　者：李建惠[1] 王周玉[1] 蒋珍菊[1] 蒋胜前[1] 

机构地区：[1]西华大学制药工程系,四川成都610039

出　　处：《化学试剂》2010年第3期227-230,260,共5页Chemical Reagents

基　　金：四川省教育厅青年基金资助项目(09205035);四川省重点学科项目;西华大学人才培养基金项目(R0720523)

摘　　要：α,β-不饱和羰基化合物的选择性还原具有很重要的应用意义,同时具有很大挑战性,利用有机小分子催化剂、以二氢吡啶酯为氢源可以高化学选择性、高对映选择性地催化还原α,β-不饱和羰基化合物的共轭双键。综述了有机小分子催化剂在α,β-不饱和醛、酮、酯以及串联反应中共轭碳碳双键选择性催化还原的研究进展,总结了每一催化体系的优缺点。The selective reduction of α,β-unsaturated carbonyl compounds is a process with significantly valuable but challenging significance.Organocatalysts can reduce the conjugate C=C bonds with high chemoselectivity and enantioselectivity using the Hantzsch esters（dihydropyridine esters） as the hydrogen source.This review focused on recent developments in selectively organocatalytic reduction of conjugate C=C bonds in the α,β-unsaturated aldehydes,α,β-unsaturated ketones,α,β-unsaturated esters and cascade reactions.The potential strengths of each catalytic system as well as its weaknesses were discussed.

关 键 词：有机小分子催化剂 不饱和羰基化合物 二氢吡啶酯 催化还原 

分 类 号：O621.3[理学—有机化学] O643.3[理学—化学]