微分脉冲阳极溶出伏安法测定氢溴酸右美沙芬  

Determination of dextromethorphan hydrobromide by differential pulse anodic stripping voltammetry

作　　者：林晓华[1] 王桂芬[1] 王爽[1] 许桂花[1] 王清珊[1] 

机构地区：[1]延边大学化学系,吉林延吉133002

出　　处：《化学试剂》2010年第3期235-238,共4页Chemical Reagents

摘　　要：应用循环伏安法和微分脉冲阳极溶出伏安法在玻碳电极上对氢溴酸右美沙芬的伏安行为进行了研究。实验结果表明,在pH6.5的B-R（Britton-Robinson）缓冲底液中,氢溴酸右美沙芬在＋1.01 V（vs.Ag/AgCl）处有一明显的氧化峰,在4.0×10-6-8.0×10-5mol/L范围内与峰电流呈良好的线性关系（r=0.995 1）,检出限为5.6×10-7mol/L。用该方法对氢溴酸右美沙芬片进行了测定,回收率为98.6%-102.9%,结果令人满意,还对其电极反应机理进行了初步探讨。The voltammetric behavior of dextromethorphan hydrobromide was studied by cyclic voltammetry and differential pulse anodic stripping voltammetry using a glass carbon electrode.In a Britton-Robinson（B-R） buffer solution with a pH value of 6.5,the oxidation peak potential was at ＋1.01 V（vs.Ag/AgCl）.There was a good linear relationship between the peak current and dextromethorphan hydrobromide concentration in the range of 4.0×10-6～8.0×10-5 mol/L,and the detection limit was 5.6×10-7 mol/L.The detected recovery of dextromethorphan hydrobromide tablets with differential pulse anodic stripping voltammetry was in the range of 98.6%～102.9%,the results were satisfactory for application.Furthermore,the electrode reaction mechanism was preliminarily discussed.

关 键 词：微分脉冲阳极溶出伏安法 氢溴酸右美沙芬 玻碳电极 反应机理 

分 类 号：O657.1[理学—分析化学]