首发精神分裂症患者惊跳反射弱刺激抑制的临床研究  

Study of the Prepulse Inhibition of Startle Reflex in First-episode Schizophrenics

作　　者：李桂臣[1] 万晓娜[2] 洪晓虹[1] 

机构地区：[1]汕头大学精神卫生中心,广东汕头515063 [2]青岛市精神卫生中心,山东青岛266034

出　　处：《汕头大学医学院学报》2010年第1期39-41,47,共4页Journal of Shantou University Medical College

基　　金：国家"十五"科技攻关计划资助项目(2002BA711-A08);广东省医学科学技术基金资助项目(A2002459)

摘　　要：目的:探讨首发精神分裂症患者及健康正常人感觉运动门控(SG)-惊跳反射弱刺激抑制(PPI)的特点。方法:采用听感觉刺激模式对首发精神分裂症患者(患者组,36例)和健康正常人(对照组,36例)进行PPI检测,分别对两组惊跳反射的各项指标进行比较分析。结果:①两组间弱+强刺激惊跳反射波的峰潜伏期(PPL)、单独强刺激惊跳反射波的峰潜伏期(PL)和波幅(PA)比差异均无统计学意义;患者组弱+强刺激惊跳反射波幅(PPA)高于对照组(P<0.05);患者组惊跳反射弱刺激抑制率(PPI%)低于对照组(P<0.01);②对照组中PPA低于PA(P<0.01);③两组内男女性别间PPI各项指标比均无统计学意义。结论:首发精神分裂症患者存在SG功能缺陷,PPI可作为一项评价机体SG和信息处理功能内表型特征的指标。Objective： To study the characteristics of the prepulse inhibition of startle reflex（ PPI） in never-medicated, first-episode schizophrenics and healthy individuals. Method： The PPI was collected in an acoustic startle paradigm from 36 first-episode schizophrenics（SC）and 36 age-matched healthy individuals（NC）. The variations of the startle reflex were compared between two groups. Results： No significant difference was found between two groups in the PA, PL and PPL. Compared with the NC groups, the SC group exhibited significant deficits in PPI% and higher PPA. In the NC group, PPA was lower than PA（ P 〈 0.01）. No significant differences were observed in the variations of the startle reflex in the male and female between two groups. Conclusion： First-episode schizophrenics have sensorimotor gating（SG）defieits and show PPI% decrease. PPI may be sensitive intermediate phenotypie markers for information processing and SG deficits in schizophrenics.

关 键 词：首发精神分裂症 感觉运动门控 惊跳反射 弱刺激抑制 

分 类 号：R794.3[医药卫生—临床医学]