神经生长因子局部注射对骨折愈合的影响  

Effect of Nerve Growth Factor inFracture Healing

作　　者：黎新宪[1] 陈江[1] 肖继青 吴绍俊 尹忠飞 汤林利 

机构地区：[1]湖南省浏阳市人民医院骨科,410300

出　　处：《中国误诊学杂志》2010年第8期1782-1783,共2页Chinese Journal of Misdiagnostics

摘　　要：目的:探讨神经生长因子(NGF)局部注射促进骨折愈合的临床作用。方法:对68例四肢新鲜骨折患者进行骨折端经皮局部注射NGF促进骨折愈合的临床治疗观察。据骨折类型、治疗方法相同或相似的原则设立相应的对照组,对骨痂生长情况、骨折临床愈合的时间进行对比研究分析。结果:两组病例均获随访,两组骨痂出现的时间、骨痂量的多少2周内无明显不同,3周后骨痂量治疗组多于对照组,治疗组各类型骨折临床愈合时间均较对照组有不同程度的缩短,疗效优于对照组,两组对比有统计学差异(P<0.01)。结论:临床应用神经生长因子经皮局部注射在骨折中后期有促进骨折愈合修复的作用。Objective：To evaluate the effect of percutaneous injection with nerve growth factor {NGF} in fracture healing. Methods： 68 cases of long bone fracture were treated by percutaneous injection with NGF in our hospi tal. The results of fracture healing time were compared between the control group and the treating group. Results：All of 68 cases were followed--up from 3 months to 20 months. The NGF group excelled significantly the control group in aspects of quantity of callus after three weeks. Fraeture healing time were managed by statistical analysis, P〈0.01, there were significant difference between the control group and the treating group. Conclusion：Fracture healing can be promoted by percutaneous injection with nerve growth factor[ NGF）.

关 键 词：神经生长因子/治疗应用 骨折愈合/药物作用 

分 类 号：R683[医药卫生—骨科学]