白矾对小鼠肠道菌群的影响  

Influence of Alum on Intestinal Flora in Mice

作　　者：严梅桢[1] 宋红月[1] 张粒民 王彦礼[1] 伍迎红[1] 周钟鸣[1] 

机构地区：[1]中国中医研究院中药研究所

出　　处：《中国中药杂志》1998年第12期743-745,共3页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金

摘　　要：目的：观察白矾对正常机体肠道微生态平衡的影响。方法：用白矾０．２５，１ｇ／ｋｇ两个剂量喂饲小鼠０．５，２和３个月，分别对小鼠进行肠道菌群分析。结果：动物口服白矾后，其肠道菌群发生紊乱，表现在肠道中与机体生理活动关系密切的生理性细菌双歧杆菌和乳杆菌菌量明显下降，致病菌大肠杆菌数量显著上升，而且服用白矾时间越长，对肠道微生态平衡影响越大。结论：白矾能引起小鼠肠道菌群失调。Objective:To observe the influence of alum on the intestinal microecological balance in normal microorganisms.Method:The mice were administered orally with alum of a small dosage(0.25/kg)and a large dosage(1g/kg)for halfa month,two months and three months,and amicroflora analysis of the micewasxarried out at intervals of the abovementioned adminostrations.Result:The intestinal flora in the animals administered with alum was imbalanced.The counts of bifidobacteria and lactobacilli closely realated to human physiological activities were decreased.The counts of pathogenic E.Coli significantly increased;and the longer the animals were treated with alum,the stronger the microecological balance was influenced.Conclusion:Alum could induce imbalance of the normal intestinal flora in mice.

关 键 词：白矾 肠道菌群 微生态平衡 

分 类 号：R285.5[医药卫生—中药学]