PKCγ的功能概述  

The Function of PKCγ

作　　者：刘峰[1] 田玉科[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院麻醉科教研室,武汉430030

出　　处：《医学综述》2010年第5期656-658,共3页Medical Recapitulate

基　　金：国家自然科学基金(30672027);高等学校博士学科点专项科研基金(20060487046)

摘　　要：蛋白激酶Cγ亚型(PKCγ)为PKC家族一员,它能在磷脂酰丝氨酸存在下被钙离子和二酰甘油激活,主要表达于中枢神经系统和外周神经元。PKCγ参与疼痛过敏和转导、海马区长时易化的改变、空间记忆学习和浦肯野细胞运动协调等。PKCγ基因点突变可诱发遗传性色素性视网膜炎、脊髓小脑共济失调和肿瘤等。Protein kinase Cγ（PKCγ）is a member of PKC family,which is activated by calcium ion and lipid diacylglycerol in the presence of phosphatidylserine.It is mainly expressed in the central nervous system and peripheral neurons.PKCγ participates the process of hyperalgesia,pain transduction,changes of LTP in the hippocampus,spatial learning memory,and movement coordination of Purkinje cells.Point mutation of PKCγ gene can induce inherited retinitis pigmentosa,spinocerebellar ataxia and tumors.

关 键 词：蛋白激酶Cγ亚型 N-甲基-D-天冬氨酸受体 长时易化 痛觉过敏 

分 类 号：R338.2[医药卫生—人体生理学]