HLA基因与硬皮病相关性的研究进展  

The Progress of HLA Gene and Scleroderma Dependability

作　　者：韩福海[1] 严煜林[1] 

机构地区：[1]广西医科大学第一附属医院皮肤科,南宁530021

出　　处：《医学综述》2010年第5期670-672,共3页Medical Recapitulate

摘　　要：硬皮病的病因及发病机制尚未明确。关于其病因及发病机制有以下学说:遗传学说、自身免疫紊乱学说、细胞外间质代谢异常学说、血管病变学说、细胞因子异常学说。其中人类白细胞抗原基因与硬皮病的相关性是目前研究热点之一。HLA-Ⅰ、HLA-Ⅱ、HLA-Ⅲ类基因与硬皮病均有相关性。其中HLA-Ⅱ类基因中的HLA-DR、HLA-DQ与硬皮病的相关性最密切。The etiology and pathogenesis of scleroderma remains unclear.Its etiology and pathogenesis has the following theories：genetic theory,autoimmune disorders,extracellular matrix metabolic disorder,vascular lesion,cytokine abnormality.Currently,it becomes a hot spot to research the relationship between human leucocyte antigen（HLA）gene and scleroderma.The researches discovered that HLA-Ⅰ、Ⅱ、Ⅲ gene have associated with scleroderma.Among these genes,the HLA-DR and HLA-DQ genes are closestly related to scleroderma.

关 键 词：硬皮病 人类白细胞抗原基因 HLA-Ⅱ类基因 HLA-DR基因 

分 类 号：R392.11[医药卫生—免疫学] R593.25[医药卫生—基础医学]