Isoket介入^(99m)Tc-MIBI心肌显像法检测犬心肌存活力  

Myocardium viability investigated by 99m Tc MIBI imaging after the intervention of isoketinfusion

作　　者：王赞[1] 王全师[1] 王桂珍[1] 郭喜海[2] 

机构地区：[1]白求恩医科大学第一临床学院 [2]吉林省人民医院

出　　处：《中国老年学杂志》1998年第6期367-368,共2页Chinese Journal of Gerontology

基　　金：吉林省科委科研基金

摘　　要：目的通过动物实验探讨二硝酸异山梨醇酯（Ｉｓｏｋｅｔ）介入９９ｍＴｃ－ＭＩＢＩ显像在心肌存活力估测中的价值。方法用结扎左冠状动脉前降支的方法制成９只犬心肌梗死模型，随机分为三组（Ⅰ、Ⅱ、Ⅲ组）分别于冠状动脉结扎１．５ｈ、３．０ｈ、６．０ｈ再灌注。对９只犬心肌梗死再灌注模型进行静息９９ｍＴｃ－ＭＩＢＩ、Ｉｓｏｋｅｔ介入９９ｍＴｃ－ＭＩＢＩ心肌断层显像。结果３组犬在静息心肌显像中的１９、２３、２５个放射性分布异常节段各有１０个节段出现放射性填充，分别占５２．６％、４３．３％、４０．０％，Ｉｓｏｋｅｔ介入后，三组犬的放射分布得分亦降低。结论Ｉｓｏｋｅｔ能明显提高９９ｍＴｃ－ＭＩＢＩ对心肌存活力的估计，Ｉｓｏｋｅｔ介入９９ｍＴｃ－ＭＩＢＩ显像是评估心肌存活力的实用方法。cannies myocardiac infarct models were performed by tying the left anterior descending artery, and were evenly divided into three groups at random. Gronp Ⅰ were reperfused 1.5 hours after myocardiac infarction; Group Ⅱ、Ⅲ for 3.0 hours and 6.0 hours respectively. 99m Tc MIBI imaging and Isoket infusion 99m Tc MIBI imaging 19, 23, 25 segments were abnormal in group Ⅰ、Ⅱ、Ⅲ respectively in rest imaging; 10 segments were improved respectively in Isoket infusion imaging. Compared with rest 99m Tc MIBI imaging, Isoket infusion 99m Tc MIBI imaging improved the estamation of infarct myocardium viability in group Ⅰ、Ⅱ、Ⅲ by 52.6%, 45.4%, 40%. The radioactive distribution scores of group Ⅰ、Ⅱ、Ⅲ all decreased in Isoket infusion imaging, which shows that Isoket infusion can improve the estamate effect of 99m Tc MIBI to myocardium viability.

关 键 词：放射性核素 显像 二硝酸 梨山梨醇醌 心肌存活力 

分 类 号：R817.42[医药卫生—影像医学与核医学]