注射用黄芪冻干粉对心肌缺血犬血流动力学的影响  

Influence of Lyophilized Radix Astragali Powder Injection on Hemodynamics of Dogs with Myocardial Ischemia

作　　者：江从勋[1] 古曦[1] 李莉[1] 肖华[1] 邹毅[1] 韩旭[1] 杨芳炬[1] 

机构地区：[1]四川大学华西基础医学与法医学院,成都610041

出　　处：《生物医学工程学杂志》2010年第1期75-79,共5页Journal of Biomedical Engineering

摘　　要：为观察注射用黄芪冻干粉(HQFDPI)对心肌缺血犬血流动力学和心肌耗氧量的影响。通过结扎犬左冠状动脉前降支造成急性心肌缺血模型,静脉给药,测定犬血流动力学参数及心肌耗氧量。结果发现:各用药组于药后5~30 min期间明显减慢心肌缺血犬心率(HR),明显降低(P<0.05~0.01)舒张压(DBP)、平均动脉压(MAP)压;同时,各用药组于药后10 min^4 h期间显著降低左室舒张末压(LVEDP)(P<0.05~0.01);HQFDPI各剂量组于药后10 min时还明显提高(P<0.05~0.01)心肌缺血犬最大收缩速率(+dp/dtmax);各用药组于给药后10 min^4h期间显著增加心输出量(CO),其中,HQFDPI高剂量组作用十分显著(P<0.01);各用药组于药后10 min^4 h期间还显著降低外周阻力(TPR)(P<0.05~0.01)、显著增加冠脉流量(CBF)(P<0.05~0.01);HQFDPI高剂量组于给药5~30 min显著降低心脏做功(MW)(P<0.05~0.01);此外,HQFDPI高剂量组和丹参组动脉血氧含量和心肌耗氧量呈显著降低趋势(P<0.05);而中、高剂量组心肌氧摄取率于药后30 min^3 h亦显著降低(P<0.05~0.01)。综上,HQFDPI能明显改善犬心肌缺血指标,显著提高心肌缺血后的心功能。In order to observe the influence of lyophilized Radix Astragali powder injection on hemodynamics and myocardial consumption of oxygen of dogs with myocardial ischemia,we establised the myocardial ischemia model by ligating the anterior descending branch of left coronary artery of 5 mongrel dogs.Then the drugs were administered intravenously,and the hemodynamic parameters and myocardial consumption of oxygen of the dogs were measured.All the Radix Astragali groups and Radix Salviae Miltiorrhizae Group（RSMG） showed significantly decreased heart rate（HR）,diastolic blood pressure（DBP）,mean arterial pressure（MAP） of dogs with myocardial ischemia in 5-30 min after drug administration（P〈0.05-0.01）.All the Radix Astragali groups and the RSMG showed significantly lowered left ventricular end-diastolic pressure（LVEDP） of the dogs in 10min-4h after drug administration（P〈0.05-0.01）.All the Radix Astragali groups displayed significantly increased maximum contraction velocity（＋dp/dtmax） of the dogs in 10 min after drug administration（P〈0.05-0.01）.All the Radix Astragali groups and the RSMG displayed significantly increased cardiac output（CO） in 10min-4h after drug administration,in which the High Dose Group（HDG） of Radix Astragali displayed the highest statistical significance（P〈0.01）.All the Radix Astragali groups and the RSMG exhibited significantly decreased peripheral resistance（TPR） and increased coronary blood flow（CBF） in 10min-4h after drug administration（P〈0.05-0.01）.HDG showed significantly decreased myocardial work（MW） in 5min-30min after drug administration（P〈0.05-0.01）.HDG and MDG exhibited significantly decreased oxygen uptake rate of the myocardium（MVo2） in 30min-3h after drug administration（P〈0.05-0.01）.In summary,the lyophilized Radix Astragali powder injection can significantly benefit all the indexes and strengthen the heart function of the dogs with myocardial ischemia.

关 键 词：注射用黄芪冻干粉 心肌缺血 血流动力学 心肌耗氧量 

分 类 号：R285.5[医药卫生—中药学]