包衣工艺参数对马来酸替加色罗pH依赖型缓释片释放度的影响  

Effects of Coating Parameters on Release rate of a pH-dependent Sustained Release Tablet of Tegaserod Maleate

作　　者：王桂玲[1] 张双庆[2] 张毅[3] 

机构地区：[1]北京大学药学院药剂学系,北京100191 [2]军事医学科学院毒物药物研究所,北京100850 [3]中国中医科学院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2010年第3期4-7,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:研究各种包衣工艺参数对马来酸替加色罗pH依赖型缓释片释放度的影响。方法:考察包衣温度,包衣锅转速,雾化压力,喷雾速度,喷雾距离和包衣液预热温度对缓释片药物释放度的影响,并用相似因子法对释放度进行评价。结果:在所考察的各个包衣工艺参数水平上,包衣温度对药物释放度有显著影响,其余各因素无显著影响。结论:确定最终包衣工艺参数为:包衣温度为30℃,包衣锅转速为25 rpm,雾化压力0.6 MPa,喷雾速度为5 mL.min-1,喷雾距离17 cm。包衣液预热温度为30℃。Objective：To investigate the effects of various coating parameters on release of a pH-dependent sustained release tablet of tegaserod maleate.Methods： Coating parameters,such as coating temperature,rotation speed of coating pan,spray pressure,spray rate,spray distance and coating solution temperature,were evaluated and the release was in vestigated by similarity factor.Results： Coating temperature significantly affected drug release while other parameters hed on obvious influence on drug release.Conclusion： Optimal coating parameters were as followed： coating temperature of 30 ℃,rotation speed of 25 rpm,spray pressure of 0.6 MPa,spray rate of 5 mL·min^（-1）,spray distance of 17 cm and coating solution temperature of 30 ℃.

关 键 词：马来酸替加色罗 pH依赖型缓释片 包衣工艺参数 

分 类 号：R283.6[医药卫生—中药学]