ICU铜绿假单胞菌肺部感染的临床分析  

Monitoring of Drug-resistance of Pulmonary Infection Caused by Pseudomonas aeruginosa in Center ICU

作　　者：张凤华[1] 王大利 王晶[1] 韩丽霞[1] 贾玉杰[3] 

机构地区：[1]大连医科大学第一临床学院检验科,辽宁大连116011 [2]大连机车医院检验科,辽宁大连116021 [3]大连医科大学病理生理教研室,辽宁大连116044

出　　处：《中华医院感染学杂志》2010年第6期875-877,共3页Chinese Journal of Nosocomiology

基　　金：大连医科大学第一临床学院青年启动基金(QN200819)

摘　　要：目的探讨重症监护病房(ICU)铜绿假单胞菌感染的临床表现、易感因素及耐药监测。方法回顾性分析2008年1～12月某院中心ICU连续分离的66株铜绿假单胞菌感染的临床资料。结果患者均为医院感染,多伴有洋葱伯克霍尔德菌等其他致病菌检出;抗菌药物体外敏感试验敏感率>50.0%的仅有阿米卡星、环丙沙星和头孢他啶;易感因素有:高龄48例(72.3%),多次静脉穿刺66例(100.0%),合并基础疾病58例(87.9%),应用广谱抗菌药物41例(62.1%),机械通气66例(100%),一次连续住院时间>14 d(100.0%)。结论铜绿假单胞菌肺部感染是医院获得性肺炎最常见的一种,可选择敏感性较高的氨基糖苷类及喹诺酮类、碳青酶烯类抗菌药物耐药性严重,值得关注。OBJECTIVE To study the Pseudomonas aeruginosa infection in ICU to provide basis for clinical therapy.METHODS The clinical data of ICU patients with P.aeruginosa infection were analyzed in 2008.RESULTS All patients were with hospital-acquired pneumonia,most of them with other pathogens grown.Antibiotic sensitivity test showed that drug resistance of bacteria was high.THe predisposing factors included old age（72.3%）,with underying diseases（87.9%）,long hospitalization time（100%）,overuse of broad-spectrum antibiotics（62.1%）and mechanical ventilation（100%）.CONCLUSIONS P.aeruginosa infection is one of the common nosocomial infections,The Multidrug resistance of the isolates of P.aeruginosa is serious,The treatment can be selected for amikacin and ciprofloxacin.The reduced susceptibility to carbapenems（including imipenem and meropenem） in P.aeruginosa should be paid attention.

关 键 词：重症监护病房 铜绿假单胞菌 耐药 

分 类 号：R378.991[医药卫生—病原生物学]