以纯化膨润土做为崩解剂的布洛芬分散片的试制  

Preparation of ibuprofen dispersible tablets using purified bentonite as the disintegrants

作　　者：白慧东[1] 蒋玉凤[1] 徐建国 

机构地区：[1]新疆自治区人民医院,新疆乌鲁木齐830001 [2]新疆药物研究所,新疆乌鲁木齐830002

出　　处：《中国医院药学杂志》2010年第5期394-396,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:考察纯化膨润土作为分散片崩解剂的性能。方法:将2种纯化膨润土与MCC、L-HPC、PVPP、CMS-Na以不同比例混合,选择不同混合崩解剂作为布洛芬分散片的崩解剂,采用均匀设计优化布洛芬分散片的处方,以溶出度T50为指标。结果:以纯化膨润土混合崩解剂制备的优化处方的布洛芬分散片溶出快,可形成较均匀的混悬液,崩解微粒可通过710微米的筛网。结论:纯化膨润土A样可作为分散片的崩解剂。OBJECTIVE To test the properties of purified bentonite as the disintegrants of dispersion tablet. METHODS Mixing bentonite, MCC ,LHPC, PVPP and CMS-Na respectively in different proportion, choice the mixed disintegrants as the disintegrants of ibuprofen dispersible tablets, Using the uniform design for selecting the best amounts of the mixed disintegrants and the amount of other addition, the dissolution rate（ T50 ）, suspensibility and disintegration time were as index. RESULTS The dissolution of the dispersible tablets was fast, could be completely formed into suspension, which could screen through the 710um mesh. CONCLUSION Purified bentonite A could be used as the disintegrants of disintegrant tablet.

关 键 词：纯化膨润土 崩解剂 分散片 

分 类 号：R943[医药卫生—药剂学]