阿司匹林在低踝臂指数患者治疗中的意义  

The therapeutic value of aspirin in patients with low ABI

作　　者：王昆[1] 戴罡[2] 胡大一[3] 

机构地区：[1]清华大学第二附属医院,北京100049 [2]中国药学会,北京100022 [3]北京大学第二附属医院,北京100044

出　　处：《中国医院药学杂志》2010年第5期402-404,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:研究阿司匹林在低踝臂指数(ABI)患者治疗中的意义。方法:连续入选低ABI的入院患者,对入选患者进行随访,观察患者出院后24个月内冠状动脉血运重建、急性心肌梗死及死亡等主要心血管不良事件(MACE)的发生情况,分析用药情况与MACE之间的关系。结果:共入选97例患者。随访发现,总计25例患者出现MACE,未用阿司匹林组较使用阿司匹林组患者MACE明显增多(37.3%和13.0%,P<0.01)。多因素的Logistic回归分析结果显示,未使用阿司匹林是低ABI患者出院后24个月内MACE的独立危险因子(P<0.05)。结论:阿司匹林可以改善低ABI患者的预后。OBJECTIVE To evaluate the therapeutic value of aspirin in patients with low ankle brachial index （ABI）. METHODS The major adverse cardiac events （MACE）, including death, non-fatal myocardial infarction and target vessel revascularization, were assessed at the end of the 24th month after these patients were discharged from hospital. The association of the adverse events with their medication usage was analyzed. RESULTS The 97 patients were enrolled. There were 51 patients in the group without taking aspirin and 46 in the group taking aspirin. The MACE occurred among 25 patients and was greater frequent among patients without taking aspirin compared with those taking aspirin （37. 3% vs 13. 0%,P〈0. 01）. Multivariate Logistic regression analysis showed that without administration of aspirin was an independent risk factor to predict the possibil- ity of the MACE （P = 0. 025）. CONCLUSION Aspirin should be given to the patients with low ABI.

关 键 词：踝臂指数 阿司匹林 

分 类 号：R543.5[医药卫生—心血管疾病] R972.9[医药卫生—内科学]