孟鲁司特联合血塞通片对改善慢性阻塞性肺疾病稳定期患者生活质量的影响  

Influence of combination of montelukast and Xue Sai-Tong tablets on the life quality of patients with chronic obstructive pulmonary disease

作　　者：吉冬元[1] 孟庆华[1] 李承红[1] 

机构地区：[1]江汉大学附属医院呼吸科,湖北武汉430015

出　　处：《中国医院药学杂志》2010年第5期407-409,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:评价孟鲁司特联合血塞通片对慢性阻塞性肺疾病(COPD)稳定期患者的生活质量影响。方法:按照预先制定的COPD患者入选及排除标准选择60例患者,采用孟鲁司特联合血塞通片治疗,治疗前及治疗终点采用呼吸系统疾病专用的St.George's呼吸问卷(SGRQ)量化评分,比较治疗前后评分变化,并对患者治疗前后SGRQ评分结果进行配对t检验及多变量相关性分析,评价患者在用药前后生存质量变化。结果:由配对t检验看出,P值均小于0.05,表明第一部分评分(呼吸症状)、第二部分评分(活动受限、疾病影响)、总评分这三个治疗前后评分差均有统计学意义;将第一部分评分、第二部分评分、总评分这三个治疗前后评分进行多变量方差分析,结果P值均小于0.01,患者治疗前后SGRQ评分差异存在统计学意义。结论:孟鲁司特联合血塞通片对提高COPD稳定期患者的生存质量有较好影响。OBJECTIVE To evaluate the influence of combination of montelukast and Xue Sai-Tong tablets on the life quality of patients with chronic obstructive pulmonary disease. METHODS Sixty patients were treated with combination of monte lukast and Xue Sai-Tong tablets. The St. George＇s respiratory questionnaire （SGRQ） was used to evaluate the difference after treatment and detect by t test and correlation analysis among various measurements. RESULTS The difference among the first part（the respiratory symptoms section score）, the second part（the activity section score, and theimpacts section score ） and the general grades was significant in statistics （P〈0. 05）. The three grades were significant different by correlation analysis among various measurements （P〈0. 01）. And the SGRQs were significant different. CONCLUSION Montelukast and Xue Sai-Tong tablet will improve the life quality of patients with COPD.

关 键 词：St.George's呼吸问卷 孟鲁司特 血塞通片 阻塞性肺疾病 稳定期 

分 类 号：R969[医药卫生—药理学]