急性心肌梗死患者血浆脂联素和超敏C-反应蛋白的临床分析  

Clinical analysis of plasma adiponectin and hs-CRP in patients with acute myocardial infarction

作　　者：马香稳[1] 王宪[1] 李建[1] 

机构地区：[1]山东省潍坊市妇幼保健院内分泌科,261011

出　　处：《中国临床实用医学》2010年第3期31-33,共3页China Clinical Practical Medicine

摘　　要：目的探讨急性心肌梗死（AMI）患者血浆脂联素（APN）和超敏C-反应蛋白（hs．CRP）的变化及其临床意义。方法选择AMI患者50例，人院后均行超声心动图检查评价室壁运动和心功能，并设对照组（30例）进行比较。采用ILISA法测定APN，免疫散射比浊法检测hs．CRP水平。结果AMI患者APN水平显著低于正常心功能对照组（P〈0．01），hs—CRP水平显著高于正常心功能对照组（P〈0．01）。AMI患者APN、hs—CRP水平与左心室射血分数（LVEF）呈负相关（r=-0．549，P〈0．01）。结论血浆APN、hs-CRP水平与预后显著相关，对AMI的辅助诊断、疗效观察及预后判断具有重要价值。Objective To explore the variation and significance of plasma adiponectin（APN）and high sensitivety C-reactive protein（hs-CRP） in patients with acute myocardial infarction（AMI）. Methods The cases were divided into two groups：AMI group（ including 50 AMI patients）and control group （including 30 normal individuals）. Plasma concentration of APN was measured by ILISA and hs-CRP was measured by immue nephelonretry. Results The concentration of APN in patients with AMI were significantly lower than those in the control group （P 〈 0. 01 ）, hs-CRP were significantly higher than those in the control group （P 〈 0. 01 ）. The concentration of APN and hs-CRP in AMI patients had a parallel rationship with LVEDD （r = 0. 549, P 〈 0,01 ）. Conclusion Plasma APN and hsCRP levels are of great value to the diagnosis,treatment and prognosis of AMI.

关 键 词：急性心肌梗死 脂联素 超敏C-反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]