含雷贝拉唑的序贯方案根除幽门螺杆菌疗效评价  

To appraise sequential(including rabeprazole)therapy for eradication of helicobacter pylori

作　　者：许秋泳[1] 许向农[1] 郑恬[1] 赖亚栋[1] 尤长乐[1] 庄涵虚[1] 方美蓉[1] 

机构地区：[1]福建医科大学附属漳州市医院消化内科,363000

出　　处：《中国实用医药》2010年第5期11-12,共2页China Practical Medicine

基　　金：福建省豪森消化科学研究基金资助项目

摘　　要：目的比较由雷贝拉唑、阿莫西林、克拉霉素、左氧氟沙星组成的10d序贯疗法与传统三联疗法根除幽门螺杆菌(Hp)的疗效。方法将经胃镜检查确诊为有明显异常的慢性胃炎和消化性溃疡且Hp阳性的患者193例随机分组,治疗组(102例)方案为前5d雷贝拉唑、阿莫西林,后5d雷贝拉唑、克拉霉素、左氧氟沙星;对照组(91例)三联疗法为雷贝拉唑、阿莫西林、克拉霉素,疗程7d。结果治疗组Hp根除率为96.1%,对照组Hp根除率为84.6%,两组比较差异有统计学意义(P<0.05)。结论以雷贝拉唑、阿莫西林、克拉霉素、左氧氟沙星组成的10d序贯疗法治疗Hp感染具有疗效高、不良反应低、依从性好之特点。Objective To compare 10 days sequential（including rabeprazole, amoxillin,clarithromycin and levofloxacin） and 7 days traditional （ including rabeprazole, amoxillin and clarithromycin） therapy for eradica- tion of helicobacter pylori. Methods 193 patients with Hp positive peptic ulcer and chronic gastritis were ran- domly divided into two groups. 102 patients were treated with rabeprazole, amoxiUin at first five days, rabe- prazole,clarithromycin and levofloxacin at the second five days. The control group（91 patients）were treated with rabeprazole,amoxillin and clarithromycin for seven days. Results The eradication rate of ten days sequential therapy was 96. 1% and that of control group was 84. 6%. Tile differences between two groups were significant （ P 〈 0. 05 ）. Conclusion Ten days sequential therapy ismore effective, well-tolerated and with higher rate of eradication.

关 键 词：序贯疗法 幽门螺杆菌 消化性溃疡 慢性胃炎 

分 类 号：R573[医药卫生—消化系统]