胃痞消对脾虚型CAG胃癌前病变大鼠外周血T细胞亚群的影响  

Effect of Weipixiao on Peripheral Blood T Cell Subsets in Chronic Atrophic Gastritis Gastric Precancerous Lesions Rats with Spleen Deficiency

作　　者：刘静[1] 潘华峰[1] 赵自明[2] 肖瑶[1] 

机构地区：[1]广州中医药大学,广州510405 [2]广东省中医研究所,广州510095

出　　处：《中药新药与临床药理》2010年第2期116-118,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：广东省自然科学基金(04010050)

摘　　要：目的观察胃痞消对脾虚型慢性萎缩性胃炎(CAG)胃癌前病变大鼠外周血T细胞亚群(CD3、CD4、CD8及CD4/CD8比值)的影响。方法采用MNNG饮水结合饥饱失常12周,复制CAG胃癌前变大鼠模型,以维酶素为对照,观察胃痞消高、中、低三个剂量连续治疗4周后对大鼠免疫功能的影响。结果胃痞消高、中、剂量可显著改善CAG胃癌前病变模型所致大鼠CD3、CD4、CD8百分率值及CD4/CD8比值的降低(P<0.01),其免疫调节作用强于维酶素(P<0.05)。结论胃痞消可能通过调节免疫功能,抑制胃癌前病变的恶性转化,从而防治CAG胃癌前病变的癌变。Objective To observe the regulation of Weipixiao, which has the actions of strengthening spleen, removing stasis and removing toxins, on peripheral blood T cells subsets （CD3, CD4, CD8 and CD4/CD8 ratio） in chronic at- rophic gastritis （CAG） gastric precancerous lesions rats with spleen dificiency. Methods The combination of MNNG drinking with dietary disorders for 12 weeks was used for the establishment of CAG rat model with gastric precancer- ous change. With vitacoenzyme tablets as the control, the effect of Weipixiao in high-, middle- and low-dose on the immune function of rats was observed after treatment for 4 successive weeks. Results High- and middle-dose Weip- ixao significantly improved the percentages of CD3,CD4 and CD8 and CD4/CD8 ratio in CAG gastric precancerous le- sions rats（P 〈 0.01 compared with the model group）, and its immune regulation was stronger than vitacoenzyme（P 〈 0.05）. Conclusion Weipixiao has preventive and therapeutic effect on CAG with gastric precancerous lesions and its mechanism is probably related with the regulation of immune function and inhibition of gastric precancerous lesions.

关 键 词：胃痞消 慢性萎缩性胃炎 胃癌前病变 T细胞亚群 大鼠 

分 类 号：R285.15[医药卫生—中药学]