石菖蒲挥发油包合工艺及包合物稳定性研究  

Study on Preparing Inclusion Compound of Volatile Oil from Rhizoma Acori Tatarinowii and Stability of Inclusion Compound

作　　者：杨小催[1] 柯雪红[1] 陈锦富[1] 王淑英[1] 

机构地区：[1]广州中医药大学第一附属医院实验中心,广州510405

出　　处：《中药新药与临床药理》2010年第2期202-205,共4页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：广东省科技攻关项目(83021)

摘　　要：目的探讨石菖蒲挥发油包合工艺,并对其包合物稳定性进行研究。方法应用U7(76)均匀试验设计对影响包合的因素进行考察,筛选出最佳包合工艺;采用HPLC法,以β-细辛醚含量为指标研究包合前后石菖蒲挥发油稳定性。结果石菖蒲挥发油的最佳包合工艺为:β-CD:挥发油=3:1,β-CD:水=1:15,包合温度为30℃,搅拌时间为3h;包合后,在考察时间范围内石菖蒲挥发油中β-细辛醚含量变化较小,RSD<5%。结论筛选出的包合工艺稳定可行,采用β-CD包合可有效提高石菖蒲挥发油的稳定性。Objective To prepare the inclusion compound of volatile oil from Rhizoma Acori Tatarinowii and to study the stability of the compound . Methods U7 （76） uniform design was used for the optimization of conditions for the inclusion compound of Rhizoma Acori Tatarinowii . With β-asarone content as the evaluation index, the stabil- ity of inclusion compound was examined by HPLC. Results The optimal condition for the inclusion compound of Rhizoma Acori Tatarinowii was as follows： the ratio of β-CD and volatile oil being 3 ： 1, β-CD ： water being 1 ： 15, inclusion temperature at 30 ℃, and stirring for 3 h. The stability of the inclusion compound wasis excellent and the RSD 〈 5 %. Conclusion The optimized process is stable and highly efficient. Inclusion with β--CD promotes the sta- bility of volatile oil from Rhizoma Acori Tatarinowii.

关 键 词：石菖蒲挥发油 包合工艺 稳定性 均匀设计 HPLC 

分 类 号：R284[医药卫生—中药学] TQ460.6[医药卫生—中医学]