帕瑞昔布钠对腹腔镜胆囊切除患者致炎因子的影响  

Effects of parecoxib on inflammatory factors in the patients undergoing laparoscopic cholecystectomy

作　　者：汤洁[1,2] 张野[1] 田国礼[2] 史劲飞[2] 李晶[2] 

机构地区：[1]安徽医科大学第二附属医院麻醉科,安徽合肥230601 [2]武警安徽省总队医院南区麻醉科,安徽合肥230061

出　　处：《安徽医药》2010年第4期449-451,共3页Anhui Medical and Pharmaceutical Journal

基　　金：安徽省优秀青年基金(No08040106814)

摘　　要：目的观察帕瑞昔布钠在腹腔镜胆囊切除术（laparoscopic cholecystectomy，LC）中对患者血清肿瘤坏死因子-α（TNF—α）、白细胞介素-6（IL-6）致炎因子的影响。方法择期全麻下行LC的患者30例，ASA分级Ⅰ～Ⅱ级，年龄29～64岁。随机分为三组：对照组（A组）和实验组（B1、B2组），每组10例。B1组将帕瑞昔布钠40mg稀释成2ml，B2组将帕瑞昔布钠20mg稀释成2ml，分别于全麻诱导时静脉注射，A组给予等量的生理盐水。双盲法观察麻醉诱导前（t1）、术后2h（t2）、术后24h（t3）患者血清TNF-α和IL-6的水平。结果与A组相比，B1、B2组在t2和t3时间点血清TNF—α和IL-6水平降低，B1组降低更明显，差异有统计学意义（P〈0．05）。结论帕瑞昔布钠在LC中对患者血清TNF—α和IL-6有抑制作用，且随着剂量的增加抑制作用增强。Aim To observe the effects of parecoxib on two inflammatory factors：TNF-α, IL-6 in patients undergoing laparoscopic chole- cystectomy（LC）. Methods Thirty ASA Ⅰ - Ⅱ patients aged 29 -64 yr undergoing laparoscopic cholecystectomy surgery were randomly divided into 3 groups （ n = 10 each） ： Patients in group B1 received intravenous injection of parecoxib 40 mg while induction of anesthesia, and those in group B2 received parecoxib 20 mg, group A was injected saline by the same volume. TNF-α and IL-6 were detected before anesthesia induction （t1 ） ,2 （t2 ） and 24 （t3 ） hours after the surgery. Results Compared with group A, the serum levels of TNF-α and IL-6 were decreased in group B2 at t2 and t3 , even significantly lower in group B1 （ P 〈 0.05 ）. Conclusion Parecoxib can inhibit the perioperative production of TNF-α and IL-6,whose effect was related with the dose of parecoxib.

关 键 词：帕瑞昔布钠 肿瘤坏死因子-Α 白细胞介素-6 腹腔镜胆囊切除术 

分 类 号：R657.4[医药卫生—外科学]