尼可地尔及RP 49356在高浓度胰岛素维持状态下的血管舒张作用  

The Vasorelaxation Effect of Nicorandil and RP 49356 in a States of Higher Insulin Concentration

作　　者：史道华[1] 陈斌[1] 王合平[1] 贾金焕[1] 

机构地区：[1]中国人民解放军福州医学高等专科学校

出　　处：《海峡药学》1998年第4期23-26,共4页Strait Pharmaceutical Journal

基　　金：南京军区1997年医学重点课题

摘　　要：本研究旨在高胰岛素浓度状态，比较两种不同结构的ATP敏感钾通道开放剂尼可地尔（Nic）及RP49356（RP）对离体兔胸主动脉环的舒血管作用。结果显示周Nic、RP舒张苯肾上腺素诱导的血管收缩无内皮依赖性，格列苯脲能完全阻断RP的作用，但仅部分抑制Nic的作用。亚申蓝仅对Nic的作用有部分抑制作用。Ins可加强RP的舒血管作用而对Nic的影响不明显。结果提示，RP、Nic在高胰岛素浓度状态下的血管舒张机制存在差异。The aim of this study was to compare the vasodilation effect of two types of ATP-sensitive channel openers nicorandil and RP 49356 on rabbit thoracic aortic rings in a states of higher insulin concentration. The results showed that relaxation were no differences between nicorandil and RP 49356 on phenylephrine-induced constraction both with and without endothelium rings. The vasodilation of RP 49356 was blocked completely but that of nicorandil was partially inhibited by glibenclamide. Vasorelaxation of RP 49356 was enhanced but that of nicorandil was not changed by insulin. Only effect of nicorandil was inhibited by methylene blue. It was suggested that RP 49356 and nicorandil exhibit the vasorelaxation but they had different mechanism in a states of higher insulin concentration.

关 键 词：钾通道 尼可地尔 胰岛素 血管舒张 

分 类 号：R972.4[医药卫生—药品]