中性粒细胞弹性蛋白酶在银屑病患者血清及皮损中的表达  

Expression of neutrophil elastase in serum and lesions of patients with psoriasis

作　　者：唐勇[1] 李修荣[2] 

机构地区：[1]湖南省怀化市第一人民医院皮肤科,418000 [2]湖南省怀化市第一人民医院检验科,418000

出　　处：《重庆医学》2010年第6期666-667,共2页Chongqing medicine

摘　　要：目的观察中性粒细胞弹性蛋白酶(NE)在银屑病患者皮损及血清中的表达水平,探讨其相关性。方法采用双抗体夹心ELISA法对20例寻常性银屑病患者(寻常性组)血清及皮损处组织液中NE的表达量进行检测,并与20名健康体检者(对照组)比较。银屑病患者病情严重程度采用银屑病皮损面积和严重性指数(PASI)评估。结果寻常性银屑病患者血清及皮损处组织液中NE表达水平显著高于对照组(P<0.01),其中进行期寻常性银屑病患者血清及皮损组织液中NE的表达水平要显著高于静止期,差异均有统计学意义(P<0.05)。寻常性银屑病患者血清中NE的表达水平与患者相应的PASI呈正相关(P<0.01)。结论NE可能参与了银屑病的发病,并与银屑病严重程度相关。Objective To observe the expression of neutrophil elastase（NE） in serum and lesions of the patients with psoriasis and to explore their correlation. Methods Double-sandwich ELISA was adopted to detect the expression of neutrophil elastase in serum and lesions of 20 patients with psoriasis vulgaris. Clinical severity of psoriasis vulgaris was assessed by psoriasis area and se- verity index （PASI）. Results The expression of neutrophil elastase in serum and lesions of the patients with psoriasis vulgaris were significantly higher than those in the normal controls（P〈0.01 ）. The levels of neutrophil elastase in serum and lesions of the pa tients during progressive stage were statistically higher than tbose during stationary stage（P〈0. 05）. There was a significant posi- tive correlation between the expression of NE in serum and PASt. It had statistical significance（P〈0.01 ）. Conclusion Neutrophit elastase may be involved in the patbogenesis of psoriasis vulgaris,and the expression of NE is related to the severity of psoriasis.

关 键 词：中性粒细胞弹性蛋白酶 银屑病 皮损 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]